Pathway Analysis for all methods genes merged
John Zhuang
2024-08-09
library(clusterProfiler)## ## clusterProfiler v4.12.2 Learn more at https://yulab-smu.top/contribution-knowledge-mining/
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## Please cite:
##
## S Xu, E Hu, Y Cai, Z Xie, X Luo, L Zhan, W Tang, Q Wang, B Liu, R Wang,
## W Xie, T Wu, L Xie, G Yu. Using clusterProfiler to characterize
## multiomics data. Nature Protocols. 2024, doi:10.1038/s41596-024-01020-z##
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## select## library(ggplot2)0. Loading of Results
A. Converted Genes of Selected Features
For FABIA and MOFA, we are only retaining the genes from features selected in the 10-bicluster/factor form, because biclusters/factors can be similar across different number of biclusters.
genes.glmnet = readRDS("data/sel_features/gene_converted/genes_glmnet.rds")
genes.glmnet.cox.1se = readRDS("data/sel_features/gene_converted/genes_glmnet_cox_1se.rds")
genes.squeezy = readRDS("data/sel_features/gene_converted/genes_squeezy.rds")
genes.globaltest = readRDS("data/sel_features/gene_converted/genes_globaltest.rds")
genes.fabia.bic = readRDS("data/sel_features/gene_converted/genes_fabia_extracted_by_bic.rds")
genes.mofa.bic = readRDS("data/sel_features/gene_converted/genes_mofa_extracted_by_bic.rds")
genes.mfa = readRDS("data/sel_features/gene_converted/genes_mfa.rds")
genes.fabia20.superbi = readRDS("data/sel_features/gene_converted/genes_superbiclust.fabia.rds")
genes.fabiamofa.superbi = readRDS("data/sel_features/gene_converted/genes_superbiclust.fabia_mofa.rds")
#For ggm, only those selected by the maximum possible FDRcut (named ".min" for the smallest 1e-n)). are selected.
genes.ggm = readRDS("data/sel_features/gene_converted/genes_ggm.rds")[c(-3, -5, -7, -12, -13, -16, -17, -20, -21)]
genes.all = readRDS("data/derived/unique_gene_names.rds")1. Merge all gene lists of interest for the same method into a single list.
merge.all.gene.list = function(genelist, print.genes = T, print.count = T){
out = c()
for (i in 1:length(genelist)) {
out = c(out, genelist[[i]])
}
out.u = unique(out)
if (print.genes) {
print(out.u)
}
if (print.count) {
print(paste(length(out.u), "unique genes selected."))
}
out.u
}geneNames = list("glmnet" = merge.all.gene.list(genes.glmnet),
"glmnet.cox" = merge.all.gene.list(genes.glmnet.cox.1se),
"squeezy" = merge.all.gene.list(genes.squeezy),
"globaltest" = merge.all.gene.list(genes.globaltest),
"fabia.10" = merge.all.gene.list(genes.fabia.bic),
"mofa.10" = merge.all.gene.list(genes.mofa.bic),
"mfa" = merge.all.gene.list(genes.mfa),
"fabia.20.superbiclust" = merge.all.gene.list(genes.fabia20.superbi),
"fabia.10_mofa.10.superbiclust" = merge.all.gene.list(genes.fabiamofa.superbi),
"ggm" = merge.all.gene.list(genes.ggm),
"all.ACC" = genes.all
)## [1] "NOTCH1" "ERBB2" "NF2" "KRAS" "CCND1" "AKT1" "BCL2L1"
## [8] "AR" "FASN" "RB1" "PIK3R1" "XIAP" "CHEK1" "IGF1R"
## [15] "SRSF1" "TUBA1B" "CDK1" "YBX1" "BECN1" "ERBB3" "FOXO3"
## [22] "ACACA" "E2F1" "MYC" "BCL2L11" "RAF1" "XBP1" "AKT3"
## [29] "EEF2" "EIF4G1" "GSK3B" "MSH6" "ITGA2" "KDR" "MRE11A"
## [36] "ASNS" "CDKN1A" "PEA15" "MAPK1" "STK11" "ADAR" "MAPK3"
## [43] "ACVRL1" "TSC2" "JUN" "RAB11B" "EEF2K" "DVL3" "PRKAA1"
## [50] "FOXM1" "YWHAB" "BAX" "CASP9" "CHGA" "PDK1" "TFRC"
## [57] "TP53" "CTNNB1" "MACC1" "YAP1" "CDH2" "ATM" "BIRC2"
## [64] "MAPK9" "PCNA" "SMAD4" "ETS1" "NRG1" "NOTCH3" "PGR"
## [71] "ANXA1" "SNAI2" "SQSTM1" "BCL2" "AXL" "BAK1" "CASP3"
## [78] "YWHAZ" "STAT3" "PARP1" "PRDX1" "PIK3CA" "PRKCA" "TGM2"
## [85] "MYH9" "IRS1" "TYMS" "ANXA7" "CLDN7" "CTNNA1" "RPS6"
## [92] "NDRG1" "PECAM1" "SETD2"
## [1] "94 unique genes selected."
## [1] "MRE11A" "AKT1" "RAD51" "MAPK9" "MAPK3" "STMN1" "CHEK1" "CDK1"
## [9] "EEF2K" "TYMS" "FOXM1" "XIAP" "PREX1" "RET" "TFRC" "CLDN7"
## [17] "ANXA1" "PRKCD" "WWTR1"
## [1] "19 unique genes selected."
## [1] "FN1" "G6PD" "FASN" "MSH6" "TFRC" "PDCD4"
## [1] "6 unique genes selected."
## [1] "RB1" "XIAP" "ETS1" "MAPK8" "ARID1A" "BID" "CDKN1A"
## [8] "MYC" "VHL" "CCND1" "PIK3R1" "CHEK1" "IGF1R" "SRSF1"
## [15] "TUBA1B" "ERBB3" "FOXO3" "ACACA" "BCL2" "ERBB2" "AXL"
## [22] "BAK1" "CASP3" "BCL2L11" "TP53" "YAP1" "YWHAZ" "STAT3"
## [29] "PARP1" "CTNNB1" "PRDX1" "PDK1" "PIK3CA" "PRKCA" "MAPK3"
## [36] "TFRC" "TGM2" "NCOA3" "MYH9" "IRS1" "JUN" "RAF1"
## [43] "TYMS" "ANXA7" "CLDN7" "CTNNA1" "EIF4G1" "YBX1" "RPS6"
## [50] "GAB2" "NDRG1" "PECAM1" "YWHAB" "SETD2" "FOXM1" "MAPK9"
## [57] "PRKAA1" "AKT1" "CDK1" "RAD51" "MSH6" "STMN1" "CASP9"
## [64] "PREX1" "EEF2K" "CHGA" "EZH2" "BCL2L1" "ACVRL1" "TSC2"
## [71] "CCNB1" "MRE11A" "NFKB1" "ANLN" "G6PD" "MSH2" "RICTOR"
## [78] "PEA15" "FASN" "ASNS" "ERCC1" "INPP4B" "XBP1" "RBM15"
## [85] "AR" "TSC1"
## [1] "86 unique genes selected."
## [1] "HSPA1A" "AKT1" "VHL" "MTOR" "MAPK8" "MYH9" "CDKN1A"
## [8] "FOXO3" "ATM" "CASP8" "MACC1" "PTEN" "KRAS" "NRAS"
## [15] "PTK2" "ETS1" "STAT5A" "CCND1" "YAP1" "ITGA2" "MAPK1"
## [22] "ANLN" "TGM2" "G6PD" "ESR1" "MET" "BCL2" "NOTCH3"
## [29] "IGF1R" "XIAP" "ARID1A" "BID" "YWHAZ" "CHEK1" "FN1"
## [36] "NCOA3" "GAB2" "CTNNB1" "RB1" "PIK3R1" "SRSF1" "TUBA1B"
## [43] "SQSTM1" "RBM15" "FASN" "TTF1" "PARP1" "CCNE2" "RAB25"
## [50] "MYC" "CASP3" "BCL2L11" "MSH6" "PIK3CA" "ERBB3" "CDH2"
## [57] "IGFBP2" "GATA3" "TSC1" "INPP4B" "PRDX1" "BAP1" "ERRFI1"
## [64] "CDKN1B" "IRS1" "JUN" "EZH2" "SHC1" "MAPT" "CHEK2"
## [71] "AXL" "EGFR" "CAV1" "ANXA1" "TFF1" "STAT3" "ASNS"
## [78] "FOXM1" "RET" "NDRG1" "LCN2" "RAD50" "PXN" "BRCA2"
## [85] "E2F1" "CASP9" "CDKN2A" "CCNE1" "MAPK9" "RAF1" "AKT2"
## [92] "BCL2L1" "DVL3" "SMAD3" "PRKCA" "MAPK3" "AKT1S1" "RPTOR"
## [99] "AR" "TFRC"
## [1] "100 unique genes selected."
## [1] "HSPA1A" "AKT1" "VHL" "MTOR" "MAPK8" "MYH9" "CDKN1A"
## [8] "FOXO3" "ATM" "CASP8" "MACC1" "PTEN" "KRAS" "NRAS"
## [15] "PTK2" "ETS1" "CCND1" "PIK3R1" "XIAP" "CHEK1" "IGF1R"
## [22] "SRSF1" "TUBA1B" "STAT5A" "KIT" "NCOA3" "EGFR" "EZH2"
## [29] "PTGS2" "MET" "AKT2" "YBX1" "PRKAA1" "PXN" "AXL"
## [36] "MSH2" "CASP3" "CCNE1" "YAP1" "EIF4E" "EIF4G1" "GAPDH"
## [43] "ITGA2" "PRKCA" "MAPK1" "TFRC" "YWHAE" "RAB11A" "ANLN"
## [50] "RICTOR" "TP53BP1" "BRAF" "RB1" "CTNNA1" "G6PD" "IGFBP2"
## [57] "RBM15" "FASN" "INPP4B" "TSC1" "TTF1" "PRDX1" "XBP1"
## [64] "MSH6" "PREX1" "PARP1" "CCNE2" "RAB25" "BCL2" "MYC"
## [71] "BCL2L11" "PIK3CA" "ARID1A" "BID" "GAB2" "BCL2L1" "YWHAZ"
## [78] "NF2" "STMN1" "CDK1" "CCNB1" "GATA3" "BRCA2" "MYH11"
## [85] "E2F1" "CASP9" "CDKN2A" "MAPK9" "RAF1" "DVL3" "SMAD3"
## [92] "MAPK3" "ESR1" "NOTCH3" "YWHAB" "FN1" "XRCC1" "PEA15"
## [99] "ACACA" "EEF2" "NRG1" "NDRG1" "AKT1S1" "GSK3A" "CDH2"
## [106] "TYMS" "PDK1" "FOXM1" "COL6A1" "ANXA1" "SQSTM1" "ASNS"
## [113] "ACVRL1" "AR" "MAPT" "RAD51" "ERCC1" "CDKN1B" "SMAD4"
## [120] "PDCD4" "CTNNB1" "WWTR1" "TSC2"
## [1] "123 unique genes selected."
## [1] "RB1" "XIAP" "HSPA1A" "AKT1" "VHL" "MTOR"
## [7] "MAPK8" "ETS1" "ARID1A" "BID" "MYH9" "CDKN1A"
## [13] "FOXO3" "ATM" "CASP8" "MACC1" "PTEN" "KRAS"
## [19] "NRAS" "PTK2" "CCND1" "PIK3R1" "CHEK1" "IGF1R"
## [25] "SRSF1" "TUBA1B" "STAT5A" "ERBB3" "ACACA" "KIT"
## [31] "NCOA3" "EGFR" "EZH2" "PTGS2" "MET" "AKT2"
## [37] "YBX1" "PRKAA1" "PXN" "AXL" "MYC" "MSH2"
## [43] "CASP3" "CCNE1" "YAP1" "EIF4E" "EIF4G1" "GAPDH"
## [49] "ITGA2" "PRKCA" "MAPK1" "TFRC" "YWHAE" "RAB11A"
## [55] "GAB2" "ANLN" "RICTOR" "TP53BP1" "BRAF" "SQSTM1"
## [61] "TGM2" "EEF2" "FASN" "CTNNA1" "G6PD" "COL6A1"
## [67] "ANXA1" "STMN1" "YWHAB" "CDH2" "CDK1" "PREX1"
## [73] "CCNB1" "IGFBP2" "NDRG1" "AKT1S1" "BCL2L1" "TYMS"
## [79] "STAT3" "KDR" "FOXM1" "MSH6" "RPS6" "SERPINE1"
## [85] "MAPK9" "RBM3" "LCN2" "SYP" "RBM15" "PRDX1"
## [91] "INPP4B" "XBP1" "GATA3" "TTF1" "TSC1" "MYH11"
## [97] "BRCA2" "ACVRL1" "AR" "MAPT" "CHEK2" "PRRT2"
## [103] "E2F1" "YWHAZ" "CTNNB1" "ERRFI1" "PDCD4" "ADAR"
## [109] "PEA15" "XRCC5" "PARP1" "FN1" "SHC1" "BAP1"
## [115] "SMAD3" "EEF2K" "NFE2L2" "ERCC1" "PDK1" "ANXA7"
## [121] "JUN" "PIK3R2" "ACACB" "PARK7" "DIRAS3" "GSK3A"
## [127] "SRC" "XRCC1" "SNAI2" "ASNS"
## [1] "130 unique genes selected."
## [1] "HSPA1A" "AKT1" "VHL" "MTOR" "MAPK8" "CDKN1A" "STAT5A" "MYH9"
## [9] "FOXO3" "ATM" "CASP8" "MACC1" "CCND1" "YAP1" "MAPK1" "ANLN"
## [17] "ETS1" "XIAP" "ARID1A" "BID" "NCOA3" "GAB2" "PTEN" "KRAS"
## [25] "NRAS" "PTK2" "ITGA2" "FN1" "G6PD" "GAPDH" "CTNNB1" "TGM2"
## [1] "32 unique genes selected."
## [1] "HSPA1A" "AKT1" "VHL" "MTOR" "MAPK8" "MYH9" "CDKN1A" "FOXO3"
## [9] "ATM" "CASP8" "MACC1" "STAT5A" "CCND1" "YAP1" "MAPK1" "ANLN"
## [17] "ESR1" "MET" "G6PD" "BCL2" "KRAS" "NOTCH3" "IGF1R" "ETS1"
## [25] "XIAP" "ARID1A" "BID" "PTEN" "NRAS" "PTK2" "YWHAZ" "CHEK1"
## [33] "FN1" "NCOA3" "GAB2" "ITGA2" "TGM2" "PIK3R1" "SRSF1" "TUBA1B"
## [41] "FASN" "IGFBP2" "RBM15" "GATA3" "PEA15" "INPP4B" "ACVRL1" "TSC1"
## [49] "CDK1" "PRDX1" "XBP1" "TFRC" "PREX1" "EGFR" "GAPDH" "STMN1"
## [57] "CCNB1" "FOXM1"
## [1] "58 unique genes selected."
## [1] "IGFBP2" "PDCD4" "GAPDH" "FASN" "MYH11" "TFRC"
## [7] "GATA3" "ATM" "TTF1" "G6PD" "AR" "PTEN"
## [13] "MSH6" "MSH2" "SQSTM1" "FN1" "EEF2" "HSPA1A"
## [19] "RPS6" "SYP" "CTNNB1" "TGM2" "CDH2" "CCND1"
## [25] "SERPINE1" "PRKCA" "PIK3R1" "TUBA1B" "COL6A1" "CDKN1A"
## [31] "PEA15" "CTNNA1" "NDRG1" "ERBB3" "ANXA1" "ADAR"
## [37] "YWHAZ" "YWHAB" "PXN" "ERRFI1" "EIF4G1" "STMN1"
## [43] "PIK3R2" "ITGA2" "MYH9" "YWHAE" "RAB11A" "PARP1"
## [49] "KDR" "CDK1" "BCL2L1" "CCNB1" "PREX1" "IDH3A"
## [55] "ESR1" "MET" "BAP1" "AKT2" "BCL2" "KIT"
## [61] "NCOA3" "NF2" "KRAS" "NRAS" "RB1" "PTK2"
## [67] "CDKN1B" "IRS1" "MYC" "EGFR" "JUN" "NOTCH3"
## [73] "BCL2L11" "EZH2" "RAF1" "PTGS2" "ETS1" "SHC1"
## [79] "FOXO3" "AKT1" "STAT5A" "STAT3" "XIAP" "CASP8"
## [85] "CHEK1" "DVL3" "GSK3B" "IGF1R" "MAPT" "YBX1"
## [91] "PRKAA1" "MAPK8" "SRSF1" "ARID1A" "CCNE2" "BID"
## [97] "CHEK2" "PRKCD" "RAB25" "PRRT2" "MACC1" "ACACA"
## [103] "E2F1" "AXL" "CAV1" "CASP3" "CCNE1" "TFF1"
## [109] "YAP1" "ASNS" "EIF4E" "EIF4EBP1" "FOXM1" "PRDX1"
## [115] "PIK3CA" "MAPK1" "RET" "RPS6KB1" "GAB2" "WWTR1"
## [121] "ANLN" "DIABLO" "NEK7" "RICTOR" "ERCC1" "INPP4B"
## [127] "TP53BP1" "BRAF" "LCN2" "RAD50" "NOTCH1" "RAD51"
## [133] "BECN1" "EEF2K" "AKT1S1" "ANXA7" "SMAD4" "XRCC1"
## [139] "DIRAS3" "RBM15" "VHL" "TSC1" "ACVRL1" "XBP1"
## [145] "PDK1" "RBM3" "PARK7" "ERBB2" "SMAD1" "CASP9"
## [151] "CDKN2A" "MAPK9" "SMAD3" "MAPK3"
## [1] "154 unique genes selected."print(genes.all)## [1] "DIRAS3" "MAPK14" "YAP1" "CDKN1B" "ERBB2" "G6PD"
## [7] "KDR" "ERBB3" "AKT1S1" "MAPK8" "PRKCD" "EIF4EBP1"
## [13] "IGFBP2" "RPS6KA1" "MRE11A" "FN1" "BCL2L11" "ASNS"
## [19] "SRC" "AKT2" "AKT3" "AKT1" "CDH2" "RAD51"
## [25] "MET" "NRAS" "TP53" "CLDN7" "IGF1R" "RBM15"
## [31] "BECN1" "RB1" "ESR1" "PTEN" "PIK3CA" "CDKN1A"
## [37] "GATA3" "PEA15" "SMAD3" "RAF1" "EIF4G1" "AXL"
## [43] "ATM" "MAPK1" "TP53BP1" "NEK7" "BIRC2" "NOTCH1"
## [49] "MAPK9" "YWHAZ" "VASP" "XRCC5" "ITGA2" "CASP7"
## [55] "BAP1" "STK11" "ADAR" "BRCA2" "EGFR" "CCNE1"
## [61] "FASN" "EEF2" "MTOR" "SERPINE1" "YWHAE" "MAPK3"
## [67] "INPP4B" "PCNA" "ACVRL1" "TSC1" "CHEK2" "BAK1"
## [73] "SMAD4" "TSC2" "PECAM1" "CTNNB1" "LCN2" "YBX1"
## [79] "RPS6" "NFE2L2" "MAPT" "CDH3" "PRKCA" "ANLN"
## [85] "PDCD4" "SHC1" "TTF1" "SMAD1" "STMN1" "RICTOR"
## [91] "JUN" "EIF4E" "CHEK1" "CDH1" "STAT3" "ACACA"
## [97] "WWTR1" "FOXO3" "GSK3B" "GSK3A" "PTK2" "PARK7"
## [103] "TGM2" "BCL2" "PRRT2" "RAB11B" "RAB11A" "ETS1"
## [109] "ACACB" "CDK1" "MS4A1" "EEF2K" "LCK" "KEAP1"
## [115] "E2F1" "XRCC1" "CTNNA1" "NFKB1" "RAD50" "MYC"
## [121] "IRS1" "VHL" "CCND1" "CAV1" "PIK3R1" "AR"
## [127] "PRDX1" "NCOA3" "XBP1" "BCL2L1" "TP63" "GAPDH"
## [133] "TYMS" "MSH6" "KIT" "CCNB1" "BRAF" "TUBA1B"
## [139] "MYH11" "NF2" "DVL3" "PTCH1" "NRG1" "KRT5"
## [145] "ARAF" "RPS6KB1" "MYH9" "NOTCH3" "KRAS" "PDK1"
## [151] "MAP2K1" "PRKAA1" "FOXM1" "COL6A1" "STAT5A" "XIAP"
## [157] "NDRG1" "PGR" "GAB2" "YWHAB" "PIK3R2" "ANXA1"
## [163] "EZH2" "RAB25" "ERCC1" "BAX" "BID" "ARID1A"
## [169] "TFRC" "HSPA1A" "PXN" "CCNE2" "PTGS2" "ERRFI1"
## [175] "SYP" "PARP1" "RBM3" "CASP9" "CASP3" "NAPSA"
## [181] "SYK" "RPTOR" "SETD2" "ANXA7" "BAD" "SNAI2"
## [187] "MSH2" "CASP8" "PREX1" "RET" "TFF1" "CDKN2A"
## [193] "DIABLO" "MACC1" "CHGA" "IDH3A" "SQSTM1" "KCNJ13"
## [199] "SRSF1"print("199 unique genes in total.")## [1] "199 unique genes in total."saveRDS(geneNames, file = "data/sel_features/gene_converted/genes_methods_merged.rds")2. Pathway Analysis
A. GO Classification
ggo_MF <- list()#functional profile of a geneset for Molecular Function
ggo_BP <- list()#functional profile of a geneset for Biological Process
ggo_CC <- list()#functional profile of a geneset for Cellular Component
for(z in 1:length(geneNames)){
print(z)
input <- geneNames[[z]]
ggo_MF[[z]] <- groupGO(gene=input,
OrgDb = org.Hs.eg.db,
ont="MF",
keyType="SYMBOL",
readable=TRUE)
ggo_BP[[z]] <- groupGO(gene=input,
OrgDb = org.Hs.eg.db,
ont="BP",
keyType="SYMBOL",
readable=TRUE)
ggo_CC[[z]] <- groupGO(gene=input,
OrgDb = org.Hs.eg.db,
ont="CC",
keyType="SYMBOL",
readable=TRUE)
}## [1] 1
## [1] 2
## [1] 3
## [1] 4
## [1] 5
## [1] 6
## [1] 7
## [1] 8
## [1] 9
## [1] 10
## [1] 11for(z in 1:length(geneNames)) {
print(head(ggo_MF[[z]]))
print(head(ggo_BP[[z]]))
print(head(ggo_CC[[z]]))
}## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 1 1/94
## GO:0003824 GO:0003824 catalytic activity 43 43/94
## GO:0005198 GO:0005198 structural molecule activity 4 4/94
## GO:0005215 GO:0005215 transporter activity 4 4/94
## GO:0005488 GO:0005488 binding 92 92/94
## GO:0009055 GO:0009055 electron transfer activity 0 0/94
## geneID
## GO:0003774 MYH9
## GO:0003824 ERBB2/KRAS/CCND1/AKT1/FASN/PIK3R1/XIAP/CHEK1/IGF1R/TUBA1B/CDK1/ACACA/RAF1/AKT3/EEF2/GSK3B/MSH6/KDR/ASNS/CDKN1A/MAPK1/STK11/ADAR/MAPK3/ACVRL1/RAB11B/EEF2K/PRKAA1/CASP9/PDK1/ATM/BIRC2/MAPK9/PCNA/AXL/CASP3/PARP1/PRDX1/PIK3CA/PRKCA/TGM2/TYMS/SETD2
## GO:0005198 TUBA1B/CLDN7/CTNNA1/RPS6
## GO:0005215 IGF1R/BAX/BCL2/BAK1
## GO:0005488 NOTCH1/ERBB2/NF2/KRAS/CCND1/AKT1/BCL2L1/AR/FASN/RB1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/CDK1/YBX1/BECN1/ERBB3/FOXO3/ACACA/E2F1/MYC/BCL2L11/RAF1/XBP1/AKT3/EEF2/EIF4G1/GSK3B/MSH6/ITGA2/KDR/ASNS/CDKN1A/PEA15/MAPK1/STK11/ADAR/MAPK3/ACVRL1/TSC2/JUN/RAB11B/EEF2K/DVL3/PRKAA1/FOXM1/YWHAB/BAX/CASP9/PDK1/TFRC/TP53/CTNNB1/MACC1/YAP1/CDH2/ATM/BIRC2/MAPK9/PCNA/SMAD4/ETS1/NRG1/NOTCH3/PGR/ANXA1/SNAI2/SQSTM1/BCL2/AXL/BAK1/CASP3/YWHAZ/STAT3/PARP1/PRDX1/PIK3CA/PRKCA/TGM2/MYH9/IRS1/TYMS/ANXA7/CLDN7/CTNNA1/RPS6/NDRG1/PECAM1/SETD2
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 28 28/94
## GO:0002376 GO:0002376 immune system process 46 46/94
## GO:0008152 GO:0008152 metabolic process 84 84/94
## GO:0009987 GO:0009987 cellular process 93 93/94
## GO:0016032 GO:0016032 viral process 12 12/94
## GO:0022414 GO:0022414 reproductive process 27 27/94
## geneID
## GO:0000003 NOTCH1/AKT1/BCL2L1/AR/RB1/IGF1R/CDK1/FOXO3/BCL2L11/MSH6/ITGA2/KDR/STK11/BAX/CTNNB1/ATM/PCNA/SMAD4/PGR/BCL2/AXL/BAK1/CASP3/STAT3/PARP1/PIK3CA/MYH9/CTNNA1
## GO:0002376 NOTCH1/ERBB2/AKT1/RB1/PIK3R1/XIAP/IGF1R/BECN1/FOXO3/MYC/BCL2L11/RAF1/XBP1/MSH6/ITGA2/CDKN1A/MAPK1/STK11/ADAR/MAPK3/BAX/CHGA/TFRC/TP53/CTNNB1/ATM/BIRC2/MAPK9/ETS1/ANXA1/SNAI2/SQSTM1/BCL2/AXL/BAK1/CASP3/YWHAZ/STAT3/PARP1/PRDX1/PIK3CA/PRKCA/MYH9/NDRG1/PECAM1/SETD2
## GO:0008152 NOTCH1/ERBB2/NF2/KRAS/CCND1/AKT1/AR/FASN/RB1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/CDK1/YBX1/BECN1/ERBB3/FOXO3/ACACA/E2F1/MYC/RAF1/XBP1/AKT3/EEF2/EIF4G1/GSK3B/MSH6/ITGA2/KDR/ASNS/CDKN1A/MAPK1/STK11/ADAR/MAPK3/ACVRL1/TSC2/JUN/RAB11B/EEF2K/DVL3/PRKAA1/FOXM1/YWHAB/BAX/CASP9/PDK1/TFRC/TP53/CTNNB1/MACC1/YAP1/ATM/BIRC2/MAPK9/PCNA/SMAD4/ETS1/NRG1/NOTCH3/PGR/ANXA1/SNAI2/SQSTM1/BCL2/AXL/BAK1/CASP3/YWHAZ/STAT3/PARP1/PRDX1/PIK3CA/PRKCA/TGM2/MYH9/IRS1/TYMS/ANXA7/RPS6/PECAM1/SETD2
## GO:0009987 NOTCH1/ERBB2/NF2/KRAS/CCND1/AKT1/BCL2L1/AR/FASN/RB1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/CDK1/YBX1/BECN1/ERBB3/FOXO3/ACACA/E2F1/MYC/BCL2L11/RAF1/XBP1/AKT3/EEF2/EIF4G1/GSK3B/MSH6/ITGA2/KDR/ASNS/CDKN1A/PEA15/MAPK1/STK11/ADAR/MAPK3/ACVRL1/TSC2/JUN/RAB11B/EEF2K/DVL3/PRKAA1/FOXM1/YWHAB/BAX/CASP9/CHGA/PDK1/TFRC/TP53/CTNNB1/MACC1/YAP1/CDH2/ATM/BIRC2/MAPK9/PCNA/SMAD4/ETS1/NRG1/NOTCH3/PGR/ANXA1/SNAI2/SQSTM1/BCL2/AXL/BAK1/CASP3/YWHAZ/STAT3/PARP1/PRDX1/PIK3CA/PRKCA/TGM2/MYH9/IRS1/TYMS/ANXA7/CLDN7/CTNNA1/RPS6/NDRG1/PECAM1/SETD2
## GO:0016032 NOTCH1/AKT1/CDK1/BECN1/GSK3B/ITGA2/ADAR/JUN/TFRC/TP53/BCL2/AXL
## GO:0022414 NOTCH1/AKT1/BCL2L1/AR/RB1/IGF1R/CDK1/FOXO3/BCL2L11/MSH6/ITGA2/KDR/STK11/BAX/CTNNB1/ATM/PCNA/SMAD4/PGR/BCL2/AXL/BAK1/CASP3/PARP1/PIK3CA/MYH9/CTNNA1
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 66 66/94
## GO:0044423 GO:0044423 virion component 0 0/94
## GO:0110165 GO:0110165 cellular anatomical entity 93 93/94
## geneID
## GO:0032991 NOTCH1/ERBB2/CCND1/AKT1/BCL2L1/AR/RB1/PIK3R1/CHEK1/IGF1R/SRSF1/CDK1/YBX1/BECN1/ERBB3/FOXO3/E2F1/MYC/BCL2L11/XBP1/EEF2/EIF4G1/GSK3B/MSH6/ITGA2/KDR/CDKN1A/PEA15/STK11/ADAR/ACVRL1/TSC2/JUN/DVL3/PRKAA1/FOXM1/BAX/CASP9/PDK1/TFRC/TP53/CTNNB1/YAP1/CDH2/ATM/BIRC2/PCNA/SMAD4/ETS1/NOTCH3/PGR/SNAI2/BCL2/AXL/BAK1/CASP3/STAT3/PARP1/PIK3CA/PRKCA/TGM2/MYH9/IRS1/CTNNA1/RPS6/PECAM1
## GO:0044423
## GO:0110165 NOTCH1/ERBB2/NF2/KRAS/CCND1/AKT1/BCL2L1/AR/FASN/RB1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/CDK1/YBX1/BECN1/ERBB3/FOXO3/ACACA/E2F1/MYC/BCL2L11/RAF1/XBP1/AKT3/EEF2/EIF4G1/GSK3B/MSH6/ITGA2/KDR/ASNS/CDKN1A/PEA15/MAPK1/STK11/ADAR/MAPK3/ACVRL1/TSC2/JUN/RAB11B/EEF2K/DVL3/PRKAA1/FOXM1/YWHAB/BAX/CASP9/CHGA/PDK1/TFRC/TP53/CTNNB1/MACC1/YAP1/CDH2/ATM/BIRC2/MAPK9/PCNA/SMAD4/ETS1/NRG1/NOTCH3/PGR/ANXA1/SNAI2/SQSTM1/BCL2/AXL/BAK1/CASP3/YWHAZ/STAT3/PARP1/PRDX1/PIK3CA/PRKCA/TGM2/MYH9/IRS1/TYMS/ANXA7/CLDN7/CTNNA1/RPS6/NDRG1/PECAM1/SETD2
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 0 0/19
## GO:0003824 GO:0003824 catalytic activity 11 11/19
## GO:0005198 GO:0005198 structural molecule activity 1 1/19
## GO:0005215 GO:0005215 transporter activity 0 0/19
## GO:0005488 GO:0005488 binding 18 18/19
## GO:0009055 GO:0009055 electron transfer activity 0 0/19
## geneID
## GO:0003774
## GO:0003824 AKT1/RAD51/MAPK9/MAPK3/CHEK1/CDK1/EEF2K/TYMS/XIAP/RET/PRKCD
## GO:0005198 CLDN7
## GO:0005215
## GO:0005488 AKT1/RAD51/MAPK9/MAPK3/STMN1/CHEK1/CDK1/EEF2K/TYMS/FOXM1/XIAP/PREX1/RET/TFRC/CLDN7/ANXA1/PRKCD/WWTR1
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 3 3/19
## GO:0002376 GO:0002376 immune system process 9 9/19
## GO:0008152 GO:0008152 metabolic process 16 16/19
## GO:0009987 GO:0009987 cellular process 18 18/19
## GO:0016032 GO:0016032 viral process 3 3/19
## GO:0022414 GO:0022414 reproductive process 3 3/19
## geneID
## GO:0000003 AKT1/RAD51/CDK1
## GO:0002376 AKT1/MAPK9/MAPK3/XIAP/PREX1/RET/TFRC/ANXA1/PRKCD
## GO:0008152 AKT1/RAD51/MAPK9/MAPK3/CHEK1/CDK1/EEF2K/TYMS/FOXM1/XIAP/PREX1/RET/TFRC/ANXA1/PRKCD/WWTR1
## GO:0009987 AKT1/RAD51/MAPK9/MAPK3/STMN1/CHEK1/CDK1/EEF2K/TYMS/FOXM1/XIAP/PREX1/RET/TFRC/CLDN7/ANXA1/PRKCD/WWTR1
## GO:0016032 AKT1/CDK1/TFRC
## GO:0022414 AKT1/RAD51/CDK1
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 8 8/19
## GO:0044423 GO:0044423 virion component 0 0/19
## GO:0110165 GO:0110165 cellular anatomical entity 18 18/19
## geneID
## GO:0032991 AKT1/RAD51/CHEK1/CDK1/FOXM1/RET/TFRC/WWTR1
## GO:0044423
## GO:0110165 AKT1/RAD51/MAPK9/MAPK3/STMN1/CHEK1/CDK1/EEF2K/TYMS/FOXM1/XIAP/PREX1/RET/TFRC/CLDN7/ANXA1/PRKCD/WWTR1
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 0 0/6
## GO:0003824 GO:0003824 catalytic activity 3 3/6
## GO:0005198 GO:0005198 structural molecule activity 1 1/6
## GO:0005215 GO:0005215 transporter activity 0 0/6
## GO:0005488 GO:0005488 binding 6 6/6
## GO:0009055 GO:0009055 electron transfer activity 0 0/6
## geneID
## GO:0003774
## GO:0003824 G6PD/FASN/MSH6
## GO:0005198 FN1
## GO:0005215
## GO:0005488 FN1/G6PD/FASN/MSH6/TFRC/PDCD4
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 1 1/6
## GO:0002376 GO:0002376 immune system process 4 4/6
## GO:0008152 GO:0008152 metabolic process 6 6/6
## GO:0009987 GO:0009987 cellular process 6 6/6
## GO:0016032 GO:0016032 viral process 1 1/6
## GO:0022414 GO:0022414 reproductive process 1 1/6
## geneID
## GO:0000003 MSH6
## GO:0002376 FN1/G6PD/MSH6/TFRC
## GO:0008152 FN1/G6PD/FASN/MSH6/TFRC/PDCD4
## GO:0009987 FN1/G6PD/FASN/MSH6/TFRC/PDCD4
## GO:0016032 TFRC
## GO:0022414 MSH6
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 3 3/6
## GO:0044423 GO:0044423 virion component 0 0/6
## GO:0110165 GO:0110165 cellular anatomical entity 6 6/6
## geneID
## GO:0032991 FN1/MSH6/TFRC
## GO:0044423
## GO:0110165 FN1/G6PD/FASN/MSH6/TFRC/PDCD4
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 1 1/86
## GO:0003824 GO:0003824 catalytic activity 40 40/86
## GO:0005198 GO:0005198 structural molecule activity 4 4/86
## GO:0005215 GO:0005215 transporter activity 3 3/86
## GO:0005488 GO:0005488 binding 84 84/86
## GO:0009055 GO:0009055 electron transfer activity 0 0/86
## geneID
## GO:0003774 MYH9
## GO:0003824 XIAP/MAPK8/CDKN1A/VHL/CCND1/PIK3R1/CHEK1/IGF1R/TUBA1B/ACACA/ERBB2/AXL/CASP3/PARP1/PRDX1/PDK1/PIK3CA/PRKCA/MAPK3/TGM2/NCOA3/RAF1/TYMS/SETD2/MAPK9/PRKAA1/AKT1/CDK1/RAD51/MSH6/CASP9/EEF2K/EZH2/ACVRL1/G6PD/MSH2/FASN/ASNS/ERCC1/INPP4B
## GO:0005198 TUBA1B/CLDN7/CTNNA1/RPS6
## GO:0005215 IGF1R/BCL2/BAK1
## GO:0005488 RB1/XIAP/ETS1/MAPK8/ARID1A/BID/CDKN1A/MYC/VHL/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/ERBB3/FOXO3/ACACA/BCL2/ERBB2/AXL/BAK1/CASP3/BCL2L11/TP53/YAP1/YWHAZ/STAT3/PARP1/CTNNB1/PRDX1/PDK1/PIK3CA/PRKCA/MAPK3/TFRC/TGM2/NCOA3/MYH9/IRS1/JUN/RAF1/TYMS/ANXA7/CLDN7/CTNNA1/EIF4G1/YBX1/RPS6/GAB2/NDRG1/PECAM1/YWHAB/SETD2/FOXM1/MAPK9/PRKAA1/AKT1/CDK1/RAD51/MSH6/STMN1/CASP9/PREX1/EEF2K/EZH2/BCL2L1/ACVRL1/TSC2/CCNB1/NFKB1/ANLN/G6PD/MSH2/RICTOR/PEA15/FASN/ASNS/ERCC1/INPP4B/XBP1/RBM15/AR/TSC1
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 22 22/86
## GO:0002376 GO:0002376 immune system process 46 46/86
## GO:0008152 GO:0008152 metabolic process 74 74/86
## GO:0009987 GO:0009987 cellular process 85 85/86
## GO:0016032 GO:0016032 viral process 7 7/86
## GO:0022414 GO:0022414 reproductive process 21 21/86
## geneID
## GO:0000003 RB1/IGF1R/FOXO3/BCL2/AXL/BAK1/CASP3/BCL2L11/STAT3/PARP1/CTNNB1/PIK3CA/MYH9/CTNNA1/AKT1/CDK1/RAD51/MSH6/BCL2L1/MSH2/ERCC1/AR
## GO:0002376 RB1/XIAP/ETS1/MAPK8/ARID1A/BID/CDKN1A/MYC/PIK3R1/IGF1R/FOXO3/BCL2/ERBB2/AXL/BAK1/CASP3/BCL2L11/TP53/YWHAZ/STAT3/PARP1/CTNNB1/PRDX1/PIK3CA/PRKCA/MAPK3/TFRC/MYH9/RAF1/GAB2/NDRG1/PECAM1/SETD2/MAPK9/AKT1/MSH6/PREX1/CHGA/EZH2/NFKB1/G6PD/MSH2/ERCC1/XBP1/RBM15/TSC1
## GO:0008152 RB1/XIAP/ETS1/MAPK8/ARID1A/BID/CDKN1A/MYC/VHL/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/ERBB3/FOXO3/ACACA/BCL2/ERBB2/AXL/BAK1/CASP3/TP53/YAP1/YWHAZ/STAT3/PARP1/CTNNB1/PRDX1/PDK1/PIK3CA/PRKCA/MAPK3/TFRC/TGM2/NCOA3/MYH9/IRS1/JUN/RAF1/TYMS/ANXA7/EIF4G1/YBX1/RPS6/PECAM1/YWHAB/SETD2/FOXM1/MAPK9/PRKAA1/AKT1/CDK1/RAD51/MSH6/CASP9/PREX1/EEF2K/EZH2/ACVRL1/TSC2/CCNB1/NFKB1/G6PD/MSH2/RICTOR/FASN/ASNS/ERCC1/INPP4B/XBP1/RBM15/AR/TSC1
## GO:0009987 RB1/XIAP/ETS1/MAPK8/ARID1A/BID/CDKN1A/MYC/VHL/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/ERBB3/FOXO3/ACACA/BCL2/ERBB2/AXL/BAK1/CASP3/BCL2L11/TP53/YAP1/YWHAZ/STAT3/PARP1/CTNNB1/PRDX1/PDK1/PIK3CA/PRKCA/MAPK3/TFRC/TGM2/NCOA3/MYH9/IRS1/JUN/RAF1/TYMS/ANXA7/CLDN7/CTNNA1/EIF4G1/YBX1/RPS6/GAB2/NDRG1/PECAM1/YWHAB/SETD2/FOXM1/MAPK9/PRKAA1/AKT1/CDK1/RAD51/MSH6/STMN1/CASP9/PREX1/EEF2K/CHGA/EZH2/BCL2L1/ACVRL1/TSC2/CCNB1/NFKB1/ANLN/G6PD/MSH2/RICTOR/PEA15/FASN/ASNS/ERCC1/INPP4B/XBP1/RBM15/AR/TSC1
## GO:0016032 BCL2/AXL/TP53/TFRC/JUN/AKT1/CDK1
## GO:0022414 RB1/IGF1R/FOXO3/BCL2/AXL/BAK1/CASP3/BCL2L11/PARP1/CTNNB1/PIK3CA/MYH9/CTNNA1/AKT1/CDK1/RAD51/MSH6/BCL2L1/MSH2/ERCC1/AR
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 58 58/86
## GO:0044423 GO:0044423 virion component 0 0/86
## GO:0110165 GO:0110165 cellular anatomical entity 85 85/86
## geneID
## GO:0032991 RB1/ETS1/ARID1A/CDKN1A/MYC/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/ERBB3/FOXO3/BCL2/ERBB2/AXL/BAK1/CASP3/BCL2L11/TP53/YAP1/STAT3/PARP1/CTNNB1/PDK1/PIK3CA/PRKCA/TFRC/TGM2/NCOA3/MYH9/IRS1/JUN/CTNNA1/EIF4G1/YBX1/RPS6/PECAM1/FOXM1/PRKAA1/AKT1/CDK1/RAD51/MSH6/CASP9/EZH2/BCL2L1/ACVRL1/TSC2/CCNB1/NFKB1/MSH2/RICTOR/PEA15/ERCC1/XBP1/RBM15/AR/TSC1
## GO:0044423
## GO:0110165 RB1/XIAP/ETS1/MAPK8/ARID1A/BID/CDKN1A/MYC/VHL/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/ERBB3/FOXO3/ACACA/BCL2/ERBB2/AXL/BAK1/CASP3/BCL2L11/TP53/YAP1/YWHAZ/STAT3/PARP1/CTNNB1/PRDX1/PDK1/PIK3CA/PRKCA/MAPK3/TFRC/TGM2/NCOA3/MYH9/IRS1/JUN/RAF1/TYMS/ANXA7/CLDN7/CTNNA1/EIF4G1/YBX1/RPS6/GAB2/NDRG1/PECAM1/YWHAB/SETD2/FOXM1/MAPK9/PRKAA1/AKT1/CDK1/RAD51/MSH6/STMN1/CASP9/PREX1/EEF2K/CHGA/EZH2/BCL2L1/ACVRL1/TSC2/CCNB1/NFKB1/ANLN/G6PD/MSH2/RICTOR/PEA15/FASN/ASNS/ERCC1/INPP4B/XBP1/RBM15/AR/TSC1
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 1 1/100
## GO:0003824 GO:0003824 catalytic activity 47 47/100
## GO:0005198 GO:0005198 structural molecule activity 2 2/100
## GO:0005215 GO:0005215 transporter activity 2 2/100
## GO:0005488 GO:0005488 binding 100 100/100
## GO:0009055 GO:0009055 electron transfer activity 0 0/100
## geneID
## GO:0003774 MYH9
## GO:0003824 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/KRAS/NRAS/PTK2/CCND1/MAPK1/TGM2/G6PD/MET/IGF1R/XIAP/CHEK1/NCOA3/PIK3R1/TUBA1B/FASN/PARP1/RAB25/CASP3/MSH6/PIK3CA/INPP4B/PRDX1/BAP1/EZH2/CHEK2/AXL/EGFR/ASNS/RET/RAD50/BRCA2/CASP9/CCNE1/MAPK9/RAF1/AKT2/PRKCA/MAPK3
## GO:0005198 FN1/TUBA1B
## GO:0005215 BCL2/IGF1R
## GO:0005488 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/STAT5A/CCND1/YAP1/ITGA2/MAPK1/ANLN/TGM2/G6PD/ESR1/MET/BCL2/NOTCH3/IGF1R/XIAP/ARID1A/BID/YWHAZ/CHEK1/FN1/NCOA3/GAB2/CTNNB1/RB1/PIK3R1/SRSF1/TUBA1B/SQSTM1/RBM15/FASN/TTF1/PARP1/CCNE2/RAB25/MYC/CASP3/BCL2L11/MSH6/PIK3CA/ERBB3/CDH2/IGFBP2/GATA3/TSC1/INPP4B/PRDX1/BAP1/ERRFI1/CDKN1B/IRS1/JUN/EZH2/SHC1/MAPT/CHEK2/AXL/EGFR/CAV1/ANXA1/TFF1/STAT3/ASNS/FOXM1/RET/NDRG1/LCN2/RAD50/PXN/BRCA2/E2F1/CASP9/CDKN2A/CCNE1/MAPK9/RAF1/AKT2/BCL2L1/DVL3/SMAD3/PRKCA/MAPK3/AKT1S1/RPTOR/AR/TFRC
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 31 31/100
## GO:0002376 GO:0002376 immune system process 55 55/100
## GO:0008152 GO:0008152 metabolic process 89 89/100
## GO:0009987 GO:0009987 cellular process 100 100/100
## GO:0016032 GO:0016032 viral process 9 9/100
## GO:0022414 GO:0022414 reproductive process 30 30/100
## geneID
## GO:0000003 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/ITGA2/ESR1/BCL2/IGF1R/CTNNB1/RB1/PARP1/CCNE2/CASP3/BCL2L11/MSH6/PIK3CA/IGFBP2/GATA3/ERRFI1/CDKN1B/AXL/EGFR/STAT3/RAD50/BRCA2/CCNE1/BCL2L1/AR
## GO:0002376 HSPA1A/AKT1/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/PTK2/ETS1/ITGA2/MAPK1/G6PD/ESR1/BCL2/IGF1R/XIAP/ARID1A/BID/YWHAZ/FN1/GAB2/CTNNB1/RB1/PIK3R1/SQSTM1/RBM15/PARP1/MYC/CASP3/BCL2L11/MSH6/PIK3CA/IGFBP2/GATA3/TSC1/PRDX1/BAP1/EZH2/MAPT/AXL/CAV1/ANXA1/STAT3/RET/NDRG1/LCN2/MAPK9/RAF1/SMAD3/PRKCA/MAPK3/RPTOR/TFRC
## GO:0008152 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/PTK2/ETS1/STAT5A/CCND1/YAP1/ITGA2/MAPK1/TGM2/G6PD/ESR1/MET/BCL2/NOTCH3/IGF1R/XIAP/ARID1A/BID/YWHAZ/CHEK1/FN1/NCOA3/CTNNB1/RB1/PIK3R1/SRSF1/SQSTM1/RBM15/FASN/TTF1/PARP1/CCNE2/MYC/CASP3/MSH6/PIK3CA/ERBB3/GATA3/TSC1/INPP4B/PRDX1/BAP1/ERRFI1/CDKN1B/IRS1/JUN/EZH2/SHC1/MAPT/CHEK2/AXL/EGFR/CAV1/ANXA1/TFF1/STAT3/ASNS/FOXM1/RET/LCN2/RAD50/BRCA2/E2F1/CASP9/CDKN2A/CCNE1/MAPK9/RAF1/AKT2/DVL3/SMAD3/PRKCA/MAPK3/AKT1S1/RPTOR/AR/TFRC
## GO:0009987 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/STAT5A/CCND1/YAP1/ITGA2/MAPK1/ANLN/TGM2/G6PD/ESR1/MET/BCL2/NOTCH3/IGF1R/XIAP/ARID1A/BID/YWHAZ/CHEK1/FN1/NCOA3/GAB2/CTNNB1/RB1/PIK3R1/SRSF1/TUBA1B/SQSTM1/RBM15/FASN/TTF1/PARP1/CCNE2/RAB25/MYC/CASP3/BCL2L11/MSH6/PIK3CA/ERBB3/CDH2/IGFBP2/GATA3/TSC1/INPP4B/PRDX1/BAP1/ERRFI1/CDKN1B/IRS1/JUN/EZH2/SHC1/MAPT/CHEK2/AXL/EGFR/CAV1/ANXA1/TFF1/STAT3/ASNS/FOXM1/RET/NDRG1/LCN2/RAD50/PXN/BRCA2/E2F1/CASP9/CDKN2A/CCNE1/MAPK9/RAF1/AKT2/BCL2L1/DVL3/SMAD3/PRKCA/MAPK3/AKT1S1/RPTOR/AR/TFRC
## GO:0016032 HSPA1A/AKT1/ITGA2/BCL2/JUN/AXL/EGFR/CAV1/TFRC
## GO:0022414 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/ITGA2/ESR1/BCL2/IGF1R/CTNNB1/RB1/PARP1/CCNE2/CASP3/BCL2L11/MSH6/PIK3CA/IGFBP2/GATA3/ERRFI1/CDKN1B/AXL/EGFR/RAD50/BRCA2/CCNE1/BCL2L1/AR
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 67 67/100
## GO:0044423 GO:0044423 virion component 0 0/100
## GO:0110165 GO:0110165 cellular anatomical entity 100 100/100
## geneID
## GO:0032991 HSPA1A/AKT1/MTOR/MYH9/CDKN1A/FOXO3/ATM/CASP8/ETS1/STAT5A/CCND1/YAP1/ITGA2/TGM2/ESR1/MET/BCL2/NOTCH3/IGF1R/ARID1A/CHEK1/FN1/NCOA3/CTNNB1/RB1/PIK3R1/SRSF1/RBM15/PARP1/CCNE2/MYC/CASP3/BCL2L11/MSH6/PIK3CA/ERBB3/CDH2/GATA3/TSC1/BAP1/CDKN1B/IRS1/JUN/EZH2/SHC1/MAPT/AXL/EGFR/CAV1/STAT3/FOXM1/RET/RAD50/PXN/BRCA2/E2F1/CASP9/CDKN2A/CCNE1/BCL2L1/DVL3/SMAD3/PRKCA/AKT1S1/RPTOR/AR/TFRC
## GO:0044423
## GO:0110165 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/STAT5A/CCND1/YAP1/ITGA2/MAPK1/ANLN/TGM2/G6PD/ESR1/MET/BCL2/NOTCH3/IGF1R/XIAP/ARID1A/BID/YWHAZ/CHEK1/FN1/NCOA3/GAB2/CTNNB1/RB1/PIK3R1/SRSF1/TUBA1B/SQSTM1/RBM15/FASN/TTF1/PARP1/CCNE2/RAB25/MYC/CASP3/BCL2L11/MSH6/PIK3CA/ERBB3/CDH2/IGFBP2/GATA3/TSC1/INPP4B/PRDX1/BAP1/ERRFI1/CDKN1B/IRS1/JUN/EZH2/SHC1/MAPT/CHEK2/AXL/EGFR/CAV1/ANXA1/TFF1/STAT3/ASNS/FOXM1/RET/NDRG1/LCN2/RAD50/PXN/BRCA2/E2F1/CASP9/CDKN2A/CCNE1/MAPK9/RAF1/AKT2/BCL2L1/DVL3/SMAD3/PRKCA/MAPK3/AKT1S1/RPTOR/AR/TFRC
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 2 2/123
## GO:0003824 GO:0003824 catalytic activity 59 59/123
## GO:0005198 GO:0005198 structural molecule activity 5 5/123
## GO:0005215 GO:0005215 transporter activity 2 2/123
## GO:0005488 GO:0005488 binding 123 123/123
## GO:0009055 GO:0009055 electron transfer activity 0 0/123
## geneID
## GO:0003774 MYH9/MYH11
## GO:0003824 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/KRAS/NRAS/PTK2/CCND1/PIK3R1/XIAP/CHEK1/IGF1R/TUBA1B/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/PRKAA1/AXL/MSH2/CASP3/CCNE1/GAPDH/PRKCA/MAPK1/RAB11A/BRAF/G6PD/FASN/INPP4B/PRDX1/MSH6/PARP1/RAB25/PIK3CA/CDK1/BRCA2/CASP9/MAPK9/RAF1/MAPK3/XRCC1/ACACA/EEF2/GSK3A/TYMS/PDK1/ASNS/ACVRL1/RAD51/ERCC1
## GO:0005198 TUBA1B/CTNNA1/MYH11/FN1/COL6A1
## GO:0005215 IGF1R/BCL2
## GO:0005488 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/CCND1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/ANLN/RICTOR/TP53BP1/BRAF/RB1/CTNNA1/G6PD/IGFBP2/RBM15/FASN/INPP4B/TSC1/TTF1/PRDX1/XBP1/MSH6/PREX1/PARP1/CCNE2/RAB25/BCL2/MYC/BCL2L11/PIK3CA/ARID1A/BID/GAB2/BCL2L1/YWHAZ/NF2/STMN1/CDK1/CCNB1/GATA3/BRCA2/MYH11/E2F1/CASP9/CDKN2A/MAPK9/RAF1/DVL3/SMAD3/MAPK3/ESR1/NOTCH3/YWHAB/FN1/XRCC1/PEA15/ACACA/EEF2/NRG1/NDRG1/AKT1S1/GSK3A/CDH2/TYMS/PDK1/FOXM1/COL6A1/ANXA1/SQSTM1/ASNS/ACVRL1/AR/MAPT/RAD51/ERCC1/CDKN1B/SMAD4/PDCD4/CTNNB1/WWTR1/TSC2
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 38 38/123
## GO:0002376 GO:0002376 immune system process 58 58/123
## GO:0008152 GO:0008152 metabolic process 107 107/123
## GO:0009987 GO:0009987 cellular process 123 123/123
## GO:0016032 GO:0016032 viral process 9 9/123
## GO:0022414 GO:0022414 reproductive process 38 38/123
## geneID
## GO:0000003 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/IGF1R/KIT/EGFR/PTGS2/AXL/MSH2/CASP3/CCNE1/ITGA2/RB1/CTNNA1/IGFBP2/MSH6/PARP1/CCNE2/BCL2/BCL2L11/PIK3CA/BCL2L1/CDK1/GATA3/BRCA2/ESR1/GSK3A/COL6A1/AR/RAD51/ERCC1/CDKN1B/SMAD4/CTNNB1
## GO:0002376 HSPA1A/AKT1/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/PTK2/ETS1/PIK3R1/XIAP/IGF1R/KIT/EZH2/AXL/MSH2/CASP3/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/TP53BP1/BRAF/RB1/G6PD/IGFBP2/RBM15/TSC1/PRDX1/XBP1/MSH6/PREX1/PARP1/BCL2/MYC/BCL2L11/PIK3CA/ARID1A/BID/GAB2/YWHAZ/GATA3/MAPK9/RAF1/SMAD3/MAPK3/ESR1/FN1/NDRG1/ANXA1/SQSTM1/MAPT/ERCC1/CTNNB1
## GO:0008152 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/PTK2/ETS1/CCND1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/STAT5A/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/AXL/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RICTOR/TP53BP1/BRAF/RB1/G6PD/RBM15/FASN/INPP4B/TSC1/TTF1/PRDX1/XBP1/MSH6/PREX1/PARP1/CCNE2/BCL2/MYC/PIK3CA/ARID1A/BID/YWHAZ/NF2/CDK1/CCNB1/GATA3/BRCA2/E2F1/CASP9/CDKN2A/MAPK9/RAF1/DVL3/SMAD3/MAPK3/ESR1/NOTCH3/YWHAB/FN1/XRCC1/ACACA/EEF2/NRG1/AKT1S1/GSK3A/TYMS/PDK1/FOXM1/COL6A1/ANXA1/SQSTM1/ASNS/ACVRL1/AR/MAPT/RAD51/ERCC1/CDKN1B/SMAD4/PDCD4/CTNNB1/WWTR1/TSC2
## GO:0009987 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/CCND1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/ANLN/RICTOR/TP53BP1/BRAF/RB1/CTNNA1/G6PD/IGFBP2/RBM15/FASN/INPP4B/TSC1/TTF1/PRDX1/XBP1/MSH6/PREX1/PARP1/CCNE2/RAB25/BCL2/MYC/BCL2L11/PIK3CA/ARID1A/BID/GAB2/BCL2L1/YWHAZ/NF2/STMN1/CDK1/CCNB1/GATA3/BRCA2/MYH11/E2F1/CASP9/CDKN2A/MAPK9/RAF1/DVL3/SMAD3/MAPK3/ESR1/NOTCH3/YWHAB/FN1/XRCC1/PEA15/ACACA/EEF2/NRG1/NDRG1/AKT1S1/GSK3A/CDH2/TYMS/PDK1/FOXM1/COL6A1/ANXA1/SQSTM1/ASNS/ACVRL1/AR/MAPT/RAD51/ERCC1/CDKN1B/SMAD4/PDCD4/CTNNB1/WWTR1/TSC2
## GO:0016032 HSPA1A/AKT1/EGFR/AXL/ITGA2/TFRC/BCL2/CDK1/GSK3A
## GO:0022414 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/IGF1R/KIT/EGFR/PTGS2/AXL/MSH2/CASP3/CCNE1/ITGA2/RB1/CTNNA1/IGFBP2/MSH6/PARP1/CCNE2/BCL2/BCL2L11/PIK3CA/BCL2L1/CDK1/GATA3/BRCA2/ESR1/GSK3A/COL6A1/AR/RAD51/ERCC1/CDKN1B/SMAD4/CTNNB1
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 84 84/123
## GO:0044423 GO:0044423 virion component 0 0/123
## GO:0110165 GO:0110165 cellular anatomical entity 123 123/123
## geneID
## GO:0032991 HSPA1A/AKT1/MTOR/MYH9/CDKN1A/FOXO3/ATM/CASP8/ETS1/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/STAT5A/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/YBX1/PRKAA1/PXN/AXL/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/TFRC/RAB11A/RICTOR/TP53BP1/RB1/CTNNA1/RBM15/TSC1/XBP1/MSH6/PARP1/CCNE2/BCL2/MYC/BCL2L11/PIK3CA/ARID1A/BCL2L1/CDK1/CCNB1/GATA3/BRCA2/MYH11/E2F1/CASP9/CDKN2A/DVL3/SMAD3/ESR1/NOTCH3/FN1/XRCC1/PEA15/EEF2/AKT1S1/GSK3A/CDH2/PDK1/FOXM1/COL6A1/ACVRL1/AR/MAPT/RAD51/ERCC1/CDKN1B/SMAD4/CTNNB1/WWTR1/TSC2
## GO:0044423
## GO:0110165 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/ETS1/CCND1/PIK3R1/XIAP/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/ANLN/RICTOR/TP53BP1/BRAF/RB1/CTNNA1/G6PD/IGFBP2/RBM15/FASN/INPP4B/TSC1/TTF1/PRDX1/XBP1/MSH6/PREX1/PARP1/CCNE2/RAB25/BCL2/MYC/BCL2L11/PIK3CA/ARID1A/BID/GAB2/BCL2L1/YWHAZ/NF2/STMN1/CDK1/CCNB1/GATA3/BRCA2/MYH11/E2F1/CASP9/CDKN2A/MAPK9/RAF1/DVL3/SMAD3/MAPK3/ESR1/NOTCH3/YWHAB/FN1/XRCC1/PEA15/ACACA/EEF2/NRG1/NDRG1/AKT1S1/GSK3A/CDH2/TYMS/PDK1/FOXM1/COL6A1/ANXA1/SQSTM1/ASNS/ACVRL1/AR/MAPT/RAD51/ERCC1/CDKN1B/SMAD4/PDCD4/CTNNB1/WWTR1/TSC2
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 2 2/130
## GO:0003824 GO:0003824 catalytic activity 64 64/130
## GO:0005198 GO:0005198 structural molecule activity 6 6/130
## GO:0005215 GO:0005215 transporter activity 1 1/130
## GO:0005488 GO:0005488 binding 130 130/130
## GO:0009055 GO:0009055 electron transfer activity 0 0/130
## geneID
## GO:0003774 MYH9/MYH11
## GO:0003824 XIAP/HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/KRAS/NRAS/PTK2/CCND1/PIK3R1/CHEK1/IGF1R/TUBA1B/ACACA/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/PRKAA1/AXL/MSH2/CASP3/CCNE1/GAPDH/PRKCA/MAPK1/RAB11A/BRAF/TGM2/EEF2/FASN/G6PD/CDK1/TYMS/KDR/MSH6/MAPK9/PRDX1/INPP4B/BRCA2/ACVRL1/CHEK2/ADAR/XRCC5/PARP1/BAP1/EEF2K/ERCC1/PDK1/ACACB/PARK7/DIRAS3/GSK3A/SRC/XRCC1/ASNS
## GO:0005198 TUBA1B/CTNNA1/COL6A1/RPS6/MYH11/FN1
## GO:0005215 IGF1R
## GO:0005488 RB1/XIAP/HSPA1A/AKT1/VHL/MTOR/MAPK8/ETS1/ARID1A/BID/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/ERBB3/ACACA/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MYC/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/GAB2/ANLN/RICTOR/TP53BP1/BRAF/SQSTM1/TGM2/EEF2/FASN/CTNNA1/G6PD/COL6A1/ANXA1/STMN1/YWHAB/CDH2/CDK1/PREX1/CCNB1/IGFBP2/NDRG1/AKT1S1/BCL2L1/TYMS/STAT3/KDR/FOXM1/MSH6/RPS6/SERPINE1/MAPK9/RBM3/LCN2/SYP/RBM15/PRDX1/INPP4B/XBP1/GATA3/TTF1/TSC1/MYH11/BRCA2/ACVRL1/AR/MAPT/CHEK2/PRRT2/E2F1/YWHAZ/CTNNB1/ERRFI1/PDCD4/ADAR/PEA15/XRCC5/PARP1/FN1/SHC1/BAP1/SMAD3/EEF2K/NFE2L2/ERCC1/PDK1/ANXA7/JUN/PIK3R2/ACACB/PARK7/DIRAS3/GSK3A/SRC/XRCC1/SNAI2/ASNS
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 36 36/130
## GO:0002376 GO:0002376 immune system process 63 63/130
## GO:0008152 GO:0008152 metabolic process 114 114/130
## GO:0009987 GO:0009987 cellular process 130 130/130
## GO:0016032 GO:0016032 viral process 10 10/130
## GO:0022414 GO:0022414 reproductive process 35 35/130
## geneID
## GO:0000003 RB1/AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/IGF1R/KIT/EGFR/PTGS2/AXL/MSH2/CASP3/CCNE1/ITGA2/CTNNA1/COL6A1/CDK1/IGFBP2/BCL2L1/STAT3/KDR/MSH6/GATA3/BRCA2/AR/CTNNB1/ERRFI1/PARP1/ERCC1/PARK7/DIRAS3/GSK3A/SRC
## GO:0002376 RB1/XIAP/HSPA1A/AKT1/MTOR/MAPK8/ETS1/ARID1A/BID/MYH9/CDKN1A/FOXO3/ATM/CASP8/PTK2/PIK3R1/IGF1R/KIT/EZH2/AXL/MYC/MSH2/CASP3/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/GAB2/TP53BP1/BRAF/SQSTM1/G6PD/ANXA1/PREX1/IGFBP2/NDRG1/STAT3/MSH6/SERPINE1/MAPK9/LCN2/RBM15/PRDX1/XBP1/GATA3/TSC1/MAPT/YWHAZ/CTNNB1/ADAR/XRCC5/PARP1/FN1/BAP1/SMAD3/NFE2L2/ERCC1/PIK3R2/PARK7/SRC/SNAI2
## GO:0008152 RB1/XIAP/HSPA1A/AKT1/VHL/MTOR/MAPK8/ETS1/ARID1A/BID/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/PTK2/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/STAT5A/ERBB3/ACACA/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/AXL/MYC/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RICTOR/TP53BP1/BRAF/SQSTM1/TGM2/EEF2/FASN/G6PD/COL6A1/ANXA1/YWHAB/CDK1/PREX1/CCNB1/AKT1S1/TYMS/STAT3/KDR/FOXM1/MSH6/RPS6/SERPINE1/MAPK9/RBM3/LCN2/RBM15/PRDX1/INPP4B/XBP1/GATA3/TTF1/TSC1/BRCA2/ACVRL1/AR/MAPT/CHEK2/E2F1/YWHAZ/CTNNB1/ERRFI1/PDCD4/ADAR/XRCC5/PARP1/FN1/SHC1/BAP1/SMAD3/EEF2K/NFE2L2/ERCC1/PDK1/ANXA7/JUN/PIK3R2/ACACB/PARK7/DIRAS3/GSK3A/SRC/XRCC1/SNAI2/ASNS
## GO:0009987 RB1/XIAP/HSPA1A/AKT1/VHL/MTOR/MAPK8/ETS1/ARID1A/BID/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/ERBB3/ACACA/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MYC/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/GAB2/ANLN/RICTOR/TP53BP1/BRAF/SQSTM1/TGM2/EEF2/FASN/CTNNA1/G6PD/COL6A1/ANXA1/STMN1/YWHAB/CDH2/CDK1/PREX1/CCNB1/IGFBP2/NDRG1/AKT1S1/BCL2L1/TYMS/STAT3/KDR/FOXM1/MSH6/RPS6/SERPINE1/MAPK9/RBM3/LCN2/SYP/RBM15/PRDX1/INPP4B/XBP1/GATA3/TTF1/TSC1/MYH11/BRCA2/ACVRL1/AR/MAPT/CHEK2/PRRT2/E2F1/YWHAZ/CTNNB1/ERRFI1/PDCD4/ADAR/PEA15/XRCC5/PARP1/FN1/SHC1/BAP1/SMAD3/EEF2K/NFE2L2/ERCC1/PDK1/ANXA7/JUN/PIK3R2/ACACB/PARK7/DIRAS3/GSK3A/SRC/XRCC1/SNAI2/ASNS
## GO:0016032 HSPA1A/AKT1/EGFR/AXL/ITGA2/TFRC/CDK1/ADAR/JUN/GSK3A
## GO:0022414 RB1/AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/IGF1R/KIT/EGFR/PTGS2/AXL/MSH2/CASP3/CCNE1/ITGA2/CTNNA1/COL6A1/CDK1/IGFBP2/BCL2L1/KDR/MSH6/GATA3/BRCA2/AR/CTNNB1/ERRFI1/PARP1/ERCC1/PARK7/DIRAS3/GSK3A/SRC
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 87 87/130
## GO:0044423 GO:0044423 virion component 0 0/130
## GO:0110165 GO:0110165 cellular anatomical entity 130 130/130
## geneID
## GO:0032991 RB1/HSPA1A/AKT1/MTOR/ETS1/ARID1A/MYH9/CDKN1A/FOXO3/ATM/CASP8/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/STAT5A/ERBB3/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/YBX1/PRKAA1/PXN/AXL/MYC/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/TFRC/RAB11A/RICTOR/TP53BP1/TGM2/EEF2/CTNNA1/COL6A1/CDH2/CDK1/CCNB1/AKT1S1/BCL2L1/STAT3/KDR/FOXM1/MSH6/RPS6/SERPINE1/RBM3/RBM15/XBP1/GATA3/TSC1/MYH11/BRCA2/ACVRL1/AR/MAPT/E2F1/CTNNB1/ADAR/PEA15/XRCC5/PARP1/FN1/SHC1/BAP1/SMAD3/NFE2L2/ERCC1/PDK1/JUN/PIK3R2/ACACB/PARK7/GSK3A/XRCC1/SNAI2
## GO:0044423
## GO:0110165 RB1/XIAP/HSPA1A/AKT1/VHL/MTOR/MAPK8/ETS1/ARID1A/BID/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/PTEN/KRAS/NRAS/PTK2/CCND1/PIK3R1/CHEK1/IGF1R/SRSF1/TUBA1B/STAT5A/ERBB3/ACACA/KIT/NCOA3/EGFR/EZH2/PTGS2/MET/AKT2/YBX1/PRKAA1/PXN/AXL/MYC/MSH2/CASP3/CCNE1/YAP1/EIF4E/EIF4G1/GAPDH/ITGA2/PRKCA/MAPK1/TFRC/YWHAE/RAB11A/GAB2/ANLN/RICTOR/TP53BP1/BRAF/SQSTM1/TGM2/EEF2/FASN/CTNNA1/G6PD/COL6A1/ANXA1/STMN1/YWHAB/CDH2/CDK1/PREX1/CCNB1/IGFBP2/NDRG1/AKT1S1/BCL2L1/TYMS/STAT3/KDR/FOXM1/MSH6/RPS6/SERPINE1/MAPK9/RBM3/LCN2/SYP/RBM15/PRDX1/INPP4B/XBP1/GATA3/TTF1/TSC1/MYH11/BRCA2/ACVRL1/AR/MAPT/CHEK2/PRRT2/E2F1/YWHAZ/CTNNB1/ERRFI1/PDCD4/ADAR/PEA15/XRCC5/PARP1/FN1/SHC1/BAP1/SMAD3/EEF2K/NFE2L2/ERCC1/PDK1/ANXA7/JUN/PIK3R2/ACACB/PARK7/DIRAS3/GSK3A/SRC/XRCC1/SNAI2/ASNS
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 1 1/32
## GO:0003824 GO:0003824 catalytic activity 19 19/32
## GO:0005198 GO:0005198 structural molecule activity 1 1/32
## GO:0005215 GO:0005215 transporter activity 0 0/32
## GO:0005488 GO:0005488 binding 32 32/32
## GO:0009055 GO:0009055 electron transfer activity 0 0/32
## geneID
## GO:0003774 MYH9
## GO:0003824 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/ATM/CASP8/CCND1/MAPK1/XIAP/NCOA3/PTEN/KRAS/NRAS/PTK2/G6PD/GAPDH/TGM2
## GO:0005198 FN1
## GO:0005215
## GO:0005488 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/STAT5A/MYH9/FOXO3/ATM/CASP8/MACC1/CCND1/YAP1/MAPK1/ANLN/ETS1/XIAP/ARID1A/BID/NCOA3/GAB2/PTEN/KRAS/NRAS/PTK2/ITGA2/FN1/G6PD/GAPDH/CTNNB1/TGM2
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 9 9/32
## GO:0002376 GO:0002376 immune system process 21 21/32
## GO:0008152 GO:0008152 metabolic process 29 29/32
## GO:0009987 GO:0009987 cellular process 32 32/32
## GO:0016032 GO:0016032 viral process 3 3/32
## GO:0022414 GO:0022414 reproductive process 9 9/32
## geneID
## GO:0000003 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/ITGA2/CTNNB1
## GO:0002376 HSPA1A/AKT1/MTOR/MAPK8/CDKN1A/MYH9/FOXO3/ATM/CASP8/MAPK1/ETS1/XIAP/ARID1A/BID/GAB2/PTK2/ITGA2/FN1/G6PD/GAPDH/CTNNB1
## GO:0008152 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/STAT5A/MYH9/FOXO3/ATM/CASP8/MACC1/CCND1/YAP1/MAPK1/ETS1/XIAP/ARID1A/BID/NCOA3/PTEN/KRAS/PTK2/ITGA2/FN1/G6PD/GAPDH/CTNNB1/TGM2
## GO:0009987 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/STAT5A/MYH9/FOXO3/ATM/CASP8/MACC1/CCND1/YAP1/MAPK1/ANLN/ETS1/XIAP/ARID1A/BID/NCOA3/GAB2/PTEN/KRAS/NRAS/PTK2/ITGA2/FN1/G6PD/GAPDH/CTNNB1/TGM2
## GO:0016032 HSPA1A/AKT1/ITGA2
## GO:0022414 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/PTEN/ITGA2/CTNNB1
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 19 19/32
## GO:0044423 GO:0044423 virion component 0 0/32
## GO:0110165 GO:0110165 cellular anatomical entity 32 32/32
## geneID
## GO:0032991 HSPA1A/AKT1/MTOR/CDKN1A/STAT5A/MYH9/FOXO3/ATM/CASP8/CCND1/YAP1/ETS1/ARID1A/NCOA3/ITGA2/FN1/GAPDH/CTNNB1/TGM2
## GO:0044423
## GO:0110165 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/STAT5A/MYH9/FOXO3/ATM/CASP8/MACC1/CCND1/YAP1/MAPK1/ANLN/ETS1/XIAP/ARID1A/BID/NCOA3/GAB2/PTEN/KRAS/NRAS/PTK2/ITGA2/FN1/G6PD/GAPDH/CTNNB1/TGM2
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 1 1/58
## GO:0003824 GO:0003824 catalytic activity 30 30/58
## GO:0005198 GO:0005198 structural molecule activity 2 2/58
## GO:0005215 GO:0005215 transporter activity 2 2/58
## GO:0005488 GO:0005488 binding 58 58/58
## GO:0009055 GO:0009055 electron transfer activity 0 0/58
## geneID
## GO:0003774 MYH9
## GO:0003824 HSPA1A/AKT1/VHL/MTOR/MAPK8/CDKN1A/ATM/CASP8/CCND1/MAPK1/MET/G6PD/KRAS/IGF1R/XIAP/PTEN/NRAS/PTK2/CHEK1/NCOA3/TGM2/PIK3R1/TUBA1B/FASN/INPP4B/ACVRL1/CDK1/PRDX1/EGFR/GAPDH
## GO:0005198 FN1/TUBA1B
## GO:0005215 BCL2/IGF1R
## GO:0005488 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/STAT5A/CCND1/YAP1/MAPK1/ANLN/ESR1/MET/G6PD/BCL2/KRAS/NOTCH3/IGF1R/ETS1/XIAP/ARID1A/BID/PTEN/NRAS/PTK2/YWHAZ/CHEK1/FN1/NCOA3/GAB2/ITGA2/TGM2/PIK3R1/SRSF1/TUBA1B/FASN/IGFBP2/RBM15/GATA3/PEA15/INPP4B/ACVRL1/TSC1/CDK1/PRDX1/XBP1/TFRC/PREX1/EGFR/GAPDH/STMN1/CCNB1/FOXM1
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 15 15/58
## GO:0002376 GO:0002376 immune system process 33 33/58
## GO:0008152 GO:0008152 metabolic process 51 51/58
## GO:0009987 GO:0009987 cellular process 58 58/58
## GO:0016032 GO:0016032 viral process 7 7/58
## GO:0022414 GO:0022414 reproductive process 15 15/58
## geneID
## GO:0000003 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/ESR1/BCL2/IGF1R/PTEN/ITGA2/IGFBP2/GATA3/CDK1/EGFR
## GO:0002376 HSPA1A/AKT1/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MAPK1/ESR1/G6PD/BCL2/IGF1R/ETS1/XIAP/ARID1A/BID/PTK2/YWHAZ/FN1/GAB2/ITGA2/PIK3R1/IGFBP2/RBM15/GATA3/TSC1/PRDX1/XBP1/TFRC/PREX1/GAPDH
## GO:0008152 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/STAT5A/CCND1/YAP1/MAPK1/ESR1/MET/G6PD/BCL2/KRAS/NOTCH3/IGF1R/ETS1/XIAP/ARID1A/BID/PTEN/PTK2/YWHAZ/CHEK1/FN1/NCOA3/ITGA2/TGM2/PIK3R1/SRSF1/FASN/RBM15/GATA3/INPP4B/ACVRL1/TSC1/CDK1/PRDX1/XBP1/TFRC/PREX1/EGFR/GAPDH/CCNB1/FOXM1
## GO:0009987 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/STAT5A/CCND1/YAP1/MAPK1/ANLN/ESR1/MET/G6PD/BCL2/KRAS/NOTCH3/IGF1R/ETS1/XIAP/ARID1A/BID/PTEN/NRAS/PTK2/YWHAZ/CHEK1/FN1/NCOA3/GAB2/ITGA2/TGM2/PIK3R1/SRSF1/TUBA1B/FASN/IGFBP2/RBM15/GATA3/PEA15/INPP4B/ACVRL1/TSC1/CDK1/PRDX1/XBP1/TFRC/PREX1/EGFR/GAPDH/STMN1/CCNB1/FOXM1
## GO:0016032 HSPA1A/AKT1/BCL2/ITGA2/CDK1/TFRC/EGFR
## GO:0022414 AKT1/MTOR/MYH9/FOXO3/ATM/CASP8/ESR1/BCL2/IGF1R/PTEN/ITGA2/IGFBP2/GATA3/CDK1/EGFR
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 37 37/58
## GO:0044423 GO:0044423 virion component 0 0/58
## GO:0110165 GO:0110165 cellular anatomical entity 58 58/58
## geneID
## GO:0032991 HSPA1A/AKT1/MTOR/MYH9/CDKN1A/FOXO3/ATM/CASP8/STAT5A/CCND1/YAP1/ESR1/MET/BCL2/NOTCH3/IGF1R/ETS1/ARID1A/CHEK1/FN1/NCOA3/ITGA2/TGM2/PIK3R1/SRSF1/RBM15/GATA3/PEA15/ACVRL1/TSC1/CDK1/XBP1/TFRC/EGFR/GAPDH/CCNB1/FOXM1
## GO:0044423
## GO:0110165 HSPA1A/AKT1/VHL/MTOR/MAPK8/MYH9/CDKN1A/FOXO3/ATM/CASP8/MACC1/STAT5A/CCND1/YAP1/MAPK1/ANLN/ESR1/MET/G6PD/BCL2/KRAS/NOTCH3/IGF1R/ETS1/XIAP/ARID1A/BID/PTEN/NRAS/PTK2/YWHAZ/CHEK1/FN1/NCOA3/GAB2/ITGA2/TGM2/PIK3R1/SRSF1/TUBA1B/FASN/IGFBP2/RBM15/GATA3/PEA15/INPP4B/ACVRL1/TSC1/CDK1/PRDX1/XBP1/TFRC/PREX1/EGFR/GAPDH/STMN1/CCNB1/FOXM1
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 2 2/154
## GO:0003824 GO:0003824 catalytic activity 71 71/154
## GO:0005198 GO:0005198 structural molecule activity 6 6/154
## GO:0005215 GO:0005215 transporter activity 2 2/154
## GO:0005488 GO:0005488 binding 154 154/154
## GO:0009055 GO:0009055 electron transfer activity 0 0/154
## geneID
## GO:0003774 MYH11/MYH9
## GO:0003824 GAPDH/FASN/ATM/G6PD/PTEN/MSH6/MSH2/EEF2/HSPA1A/TGM2/CCND1/PRKCA/PIK3R1/TUBA1B/CDKN1A/ADAR/RAB11A/PARP1/KDR/CDK1/IDH3A/MET/BAP1/AKT2/KIT/NCOA3/KRAS/NRAS/PTK2/EGFR/EZH2/RAF1/PTGS2/AKT1/XIAP/CASP8/CHEK1/GSK3B/IGF1R/PRKAA1/MAPK8/CHEK2/PRKCD/RAB25/ACACA/AXL/CASP3/CCNE1/ASNS/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/NEK7/ERCC1/INPP4B/BRAF/RAD50/RAD51/EEF2K/XRCC1/DIRAS3/VHL/ACVRL1/PDK1/PARK7/ERBB2/CASP9/MAPK9/MAPK3
## GO:0005198 MYH11/FN1/RPS6/TUBA1B/COL6A1/CTNNA1
## GO:0005215 BCL2/IGF1R
## GO:0005488 IGFBP2/PDCD4/GAPDH/FASN/MYH11/TFRC/GATA3/ATM/TTF1/G6PD/AR/PTEN/MSH6/MSH2/SQSTM1/FN1/EEF2/HSPA1A/RPS6/SYP/CTNNB1/TGM2/CDH2/CCND1/SERPINE1/PRKCA/PIK3R1/TUBA1B/COL6A1/CDKN1A/PEA15/CTNNA1/NDRG1/ERBB3/ANXA1/ADAR/YWHAZ/YWHAB/PXN/ERRFI1/EIF4G1/STMN1/PIK3R2/ITGA2/MYH9/YWHAE/RAB11A/PARP1/KDR/CDK1/BCL2L1/CCNB1/PREX1/IDH3A/ESR1/MET/BAP1/AKT2/BCL2/KIT/NCOA3/NF2/KRAS/NRAS/RB1/PTK2/CDKN1B/IRS1/MYC/EGFR/JUN/NOTCH3/BCL2L11/EZH2/RAF1/PTGS2/ETS1/SHC1/FOXO3/AKT1/STAT5A/STAT3/XIAP/CASP8/CHEK1/DVL3/GSK3B/IGF1R/MAPT/YBX1/PRKAA1/MAPK8/SRSF1/ARID1A/CCNE2/BID/CHEK2/PRKCD/RAB25/PRRT2/MACC1/ACACA/E2F1/AXL/CAV1/CASP3/CCNE1/TFF1/YAP1/ASNS/EIF4E/EIF4EBP1/FOXM1/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/GAB2/WWTR1/ANLN/DIABLO/NEK7/RICTOR/ERCC1/INPP4B/TP53BP1/BRAF/LCN2/RAD50/NOTCH1/RAD51/BECN1/EEF2K/AKT1S1/ANXA7/SMAD4/XRCC1/DIRAS3/RBM15/VHL/TSC1/ACVRL1/XBP1/PDK1/RBM3/PARK7/ERBB2/SMAD1/CASP9/CDKN2A/MAPK9/SMAD3/MAPK3
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 44 44/154
## GO:0002376 GO:0002376 immune system process 72 72/154
## GO:0008152 GO:0008152 metabolic process 136 136/154
## GO:0009987 GO:0009987 cellular process 154 154/154
## GO:0016032 GO:0016032 viral process 14 14/154
## GO:0022414 GO:0022414 reproductive process 43 43/154
## geneID
## GO:0000003 IGFBP2/GATA3/ATM/AR/PTEN/MSH6/MSH2/CTNNB1/COL6A1/CTNNA1/ERRFI1/ITGA2/MYH9/PARP1/KDR/CDK1/BCL2L1/ESR1/BCL2/KIT/RB1/CDKN1B/EGFR/BCL2L11/PTGS2/FOXO3/AKT1/STAT3/CASP8/IGF1R/CCNE2/AXL/CASP3/CCNE1/PIK3CA/RPS6KB1/ERCC1/RAD50/NOTCH1/RAD51/SMAD4/DIRAS3/PARK7/SMAD1
## GO:0002376 IGFBP2/GAPDH/TFRC/GATA3/ATM/G6PD/MSH6/MSH2/SQSTM1/FN1/HSPA1A/CTNNB1/SERPINE1/PRKCA/PIK3R1/CDKN1A/NDRG1/ANXA1/ADAR/YWHAZ/PIK3R2/ITGA2/MYH9/YWHAE/PARP1/PREX1/ESR1/BAP1/BCL2/KIT/RB1/PTK2/MYC/BCL2L11/EZH2/RAF1/ETS1/FOXO3/AKT1/STAT3/XIAP/CASP8/IGF1R/MAPT/MAPK8/ARID1A/BID/PRKCD/AXL/CAV1/CASP3/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/GAB2/NEK7/ERCC1/TP53BP1/BRAF/LCN2/NOTCH1/BECN1/RBM15/TSC1/XBP1/PARK7/ERBB2/MAPK9/SMAD3/MAPK3
## GO:0008152 PDCD4/GAPDH/FASN/TFRC/GATA3/ATM/TTF1/G6PD/AR/PTEN/MSH6/MSH2/SQSTM1/FN1/EEF2/HSPA1A/RPS6/CTNNB1/TGM2/CCND1/SERPINE1/PRKCA/PIK3R1/COL6A1/CDKN1A/ERBB3/ANXA1/ADAR/YWHAZ/YWHAB/ERRFI1/EIF4G1/PIK3R2/ITGA2/MYH9/YWHAE/PARP1/KDR/CDK1/CCNB1/PREX1/IDH3A/ESR1/MET/BAP1/AKT2/BCL2/KIT/NCOA3/NF2/KRAS/RB1/PTK2/CDKN1B/IRS1/MYC/EGFR/JUN/NOTCH3/EZH2/RAF1/PTGS2/ETS1/SHC1/FOXO3/AKT1/STAT5A/STAT3/XIAP/CASP8/CHEK1/DVL3/GSK3B/IGF1R/MAPT/YBX1/PRKAA1/MAPK8/SRSF1/ARID1A/CCNE2/BID/CHEK2/PRKCD/MACC1/ACACA/E2F1/AXL/CAV1/CASP3/CCNE1/TFF1/YAP1/ASNS/EIF4E/EIF4EBP1/FOXM1/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/WWTR1/DIABLO/NEK7/RICTOR/ERCC1/INPP4B/TP53BP1/BRAF/LCN2/RAD50/NOTCH1/RAD51/BECN1/EEF2K/AKT1S1/ANXA7/SMAD4/XRCC1/DIRAS3/RBM15/VHL/TSC1/ACVRL1/XBP1/PDK1/RBM3/PARK7/ERBB2/SMAD1/CASP9/CDKN2A/MAPK9/SMAD3/MAPK3
## GO:0009987 IGFBP2/PDCD4/GAPDH/FASN/MYH11/TFRC/GATA3/ATM/TTF1/G6PD/AR/PTEN/MSH6/MSH2/SQSTM1/FN1/EEF2/HSPA1A/RPS6/SYP/CTNNB1/TGM2/CDH2/CCND1/SERPINE1/PRKCA/PIK3R1/TUBA1B/COL6A1/CDKN1A/PEA15/CTNNA1/NDRG1/ERBB3/ANXA1/ADAR/YWHAZ/YWHAB/PXN/ERRFI1/EIF4G1/STMN1/PIK3R2/ITGA2/MYH9/YWHAE/RAB11A/PARP1/KDR/CDK1/BCL2L1/CCNB1/PREX1/IDH3A/ESR1/MET/BAP1/AKT2/BCL2/KIT/NCOA3/NF2/KRAS/NRAS/RB1/PTK2/CDKN1B/IRS1/MYC/EGFR/JUN/NOTCH3/BCL2L11/EZH2/RAF1/PTGS2/ETS1/SHC1/FOXO3/AKT1/STAT5A/STAT3/XIAP/CASP8/CHEK1/DVL3/GSK3B/IGF1R/MAPT/YBX1/PRKAA1/MAPK8/SRSF1/ARID1A/CCNE2/BID/CHEK2/PRKCD/RAB25/PRRT2/MACC1/ACACA/E2F1/AXL/CAV1/CASP3/CCNE1/TFF1/YAP1/ASNS/EIF4E/EIF4EBP1/FOXM1/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/GAB2/WWTR1/ANLN/DIABLO/NEK7/RICTOR/ERCC1/INPP4B/TP53BP1/BRAF/LCN2/RAD50/NOTCH1/RAD51/BECN1/EEF2K/AKT1S1/ANXA7/SMAD4/XRCC1/DIRAS3/RBM15/VHL/TSC1/ACVRL1/XBP1/PDK1/RBM3/PARK7/ERBB2/SMAD1/CASP9/CDKN2A/MAPK9/SMAD3/MAPK3
## GO:0016032 TFRC/HSPA1A/ADAR/ITGA2/CDK1/BCL2/EGFR/JUN/AKT1/GSK3B/AXL/CAV1/NOTCH1/BECN1
## GO:0022414 IGFBP2/GATA3/ATM/AR/PTEN/MSH6/MSH2/CTNNB1/COL6A1/CTNNA1/ERRFI1/ITGA2/MYH9/PARP1/KDR/CDK1/BCL2L1/ESR1/BCL2/KIT/RB1/CDKN1B/EGFR/BCL2L11/PTGS2/FOXO3/AKT1/CASP8/IGF1R/CCNE2/AXL/CASP3/CCNE1/PIK3CA/RPS6KB1/ERCC1/RAD50/NOTCH1/RAD51/SMAD4/DIRAS3/PARK7/SMAD1
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 104 104/154
## GO:0044423 GO:0044423 virion component 0 0/154
## GO:0110165 GO:0110165 cellular anatomical entity 154 154/154
## geneID
## GO:0032991 GAPDH/MYH11/TFRC/GATA3/ATM/AR/MSH6/MSH2/FN1/EEF2/HSPA1A/RPS6/CTNNB1/TGM2/CDH2/CCND1/SERPINE1/PRKCA/PIK3R1/COL6A1/CDKN1A/PEA15/CTNNA1/ERBB3/ADAR/PXN/EIF4G1/PIK3R2/ITGA2/MYH9/RAB11A/PARP1/KDR/CDK1/BCL2L1/CCNB1/IDH3A/ESR1/MET/BAP1/BCL2/KIT/NCOA3/RB1/CDKN1B/IRS1/MYC/EGFR/JUN/NOTCH3/BCL2L11/EZH2/PTGS2/ETS1/SHC1/FOXO3/AKT1/STAT5A/STAT3/CASP8/CHEK1/DVL3/GSK3B/IGF1R/MAPT/YBX1/PRKAA1/SRSF1/ARID1A/CCNE2/E2F1/AXL/CAV1/CASP3/CCNE1/YAP1/EIF4E/FOXM1/PIK3CA/RET/WWTR1/DIABLO/RICTOR/ERCC1/TP53BP1/RAD50/NOTCH1/RAD51/BECN1/AKT1S1/SMAD4/XRCC1/RBM15/TSC1/ACVRL1/XBP1/PDK1/RBM3/PARK7/ERBB2/SMAD1/CASP9/CDKN2A/SMAD3
## GO:0044423
## GO:0110165 IGFBP2/PDCD4/GAPDH/FASN/MYH11/TFRC/GATA3/ATM/TTF1/G6PD/AR/PTEN/MSH6/MSH2/SQSTM1/FN1/EEF2/HSPA1A/RPS6/SYP/CTNNB1/TGM2/CDH2/CCND1/SERPINE1/PRKCA/PIK3R1/TUBA1B/COL6A1/CDKN1A/PEA15/CTNNA1/NDRG1/ERBB3/ANXA1/ADAR/YWHAZ/YWHAB/PXN/ERRFI1/EIF4G1/STMN1/PIK3R2/ITGA2/MYH9/YWHAE/RAB11A/PARP1/KDR/CDK1/BCL2L1/CCNB1/PREX1/IDH3A/ESR1/MET/BAP1/AKT2/BCL2/KIT/NCOA3/NF2/KRAS/NRAS/RB1/PTK2/CDKN1B/IRS1/MYC/EGFR/JUN/NOTCH3/BCL2L11/EZH2/RAF1/PTGS2/ETS1/SHC1/FOXO3/AKT1/STAT5A/STAT3/XIAP/CASP8/CHEK1/DVL3/GSK3B/IGF1R/MAPT/YBX1/PRKAA1/MAPK8/SRSF1/ARID1A/CCNE2/BID/CHEK2/PRKCD/RAB25/PRRT2/MACC1/ACACA/E2F1/AXL/CAV1/CASP3/CCNE1/TFF1/YAP1/ASNS/EIF4E/EIF4EBP1/FOXM1/PRDX1/PIK3CA/MAPK1/RET/RPS6KB1/GAB2/WWTR1/ANLN/DIABLO/NEK7/RICTOR/ERCC1/INPP4B/TP53BP1/BRAF/LCN2/RAD50/NOTCH1/RAD51/BECN1/EEF2K/AKT1S1/ANXA7/SMAD4/XRCC1/DIRAS3/RBM15/VHL/TSC1/ACVRL1/XBP1/PDK1/RBM3/PARK7/ERBB2/SMAD1/CASP9/CDKN2A/MAPK9/SMAD3/MAPK3
## ID Description Count GeneRatio
## GO:0003774 GO:0003774 cytoskeletal motor activity 2 2/199
## GO:0003824 GO:0003824 catalytic activity 92 92/199
## GO:0005198 GO:0005198 structural molecule activity 8 8/199
## GO:0005215 GO:0005215 transporter activity 5 5/199
## GO:0005488 GO:0005488 binding 196 196/199
## GO:0009055 GO:0009055 electron transfer activity 0 0/199
## geneID
## GO:0003774 MYH11/MYH9
## GO:0003824 DIRAS3/MAPK14/ERBB2/G6PD/KDR/MAPK8/PRKCD/RPS6KA1/ASNS/SRC/AKT2/AKT3/AKT1/RAD51/MET/NRAS/IGF1R/PTEN/PIK3CA/CDKN1A/RAF1/AXL/ATM/MAPK1/NEK7/BIRC2/MAPK9/XRCC5/CASP7/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/FASN/EEF2/MTOR/MAPK3/INPP4B/PCNA/ACVRL1/CHEK2/PRKCA/CHEK1/ACACA/GSK3B/GSK3A/PTK2/PARK7/TGM2/RAB11B/RAB11A/ACACB/CDK1/EEF2K/LCK/XRCC1/RAD50/VHL/CCND1/PIK3R1/PRDX1/NCOA3/GAPDH/TYMS/MSH6/KIT/BRAF/TUBA1B/ARAF/RPS6KB1/KRAS/PDK1/MAP2K1/PRKAA1/XIAP/EZH2/RAB25/ERCC1/HSPA1A/PTGS2/PARP1/CASP9/CASP3/NAPSA/SYK/SETD2/MSH2/CASP8/RET/IDH3A
## GO:0005198 FN1/CLDN7/RPS6/CTNNA1/TUBA1B/MYH11/KRT5/COL6A1
## GO:0005215 IGF1R/BAK1/BCL2/BAX/KCNJ13
## GO:0005488 DIRAS3/MAPK14/YAP1/CDKN1B/ERBB2/G6PD/KDR/ERBB3/AKT1S1/MAPK8/PRKCD/EIF4EBP1/IGFBP2/RPS6KA1/FN1/BCL2L11/ASNS/SRC/AKT2/AKT3/AKT1/CDH2/RAD51/MET/NRAS/TP53/CLDN7/IGF1R/RBM15/BECN1/RB1/ESR1/PTEN/PIK3CA/CDKN1A/GATA3/PEA15/SMAD3/RAF1/EIF4G1/AXL/ATM/MAPK1/TP53BP1/NEK7/BIRC2/NOTCH1/MAPK9/YWHAZ/VASP/XRCC5/ITGA2/CASP7/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/FASN/EEF2/MTOR/SERPINE1/YWHAE/MAPK3/INPP4B/PCNA/ACVRL1/TSC1/CHEK2/BAK1/SMAD4/TSC2/PECAM1/CTNNB1/LCN2/YBX1/RPS6/NFE2L2/MAPT/CDH3/PRKCA/ANLN/PDCD4/SHC1/TTF1/SMAD1/STMN1/RICTOR/JUN/EIF4E/CHEK1/CDH1/STAT3/ACACA/WWTR1/FOXO3/GSK3B/GSK3A/PTK2/PARK7/TGM2/BCL2/PRRT2/RAB11B/RAB11A/ETS1/ACACB/CDK1/MS4A1/EEF2K/LCK/KEAP1/E2F1/XRCC1/CTNNA1/NFKB1/RAD50/MYC/IRS1/VHL/CCND1/CAV1/PIK3R1/AR/PRDX1/NCOA3/XBP1/BCL2L1/TP63/GAPDH/TYMS/MSH6/KIT/CCNB1/BRAF/TUBA1B/MYH11/NF2/DVL3/PTCH1/NRG1/KRT5/ARAF/RPS6KB1/MYH9/NOTCH3/KRAS/PDK1/MAP2K1/PRKAA1/FOXM1/COL6A1/STAT5A/XIAP/NDRG1/PGR/GAB2/YWHAB/PIK3R2/ANXA1/EZH2/RAB25/ERCC1/BAX/BID/ARID1A/TFRC/HSPA1A/PXN/CCNE2/PTGS2/ERRFI1/SYP/PARP1/RBM3/CASP9/CASP3/NAPSA/SYK/RPTOR/SETD2/ANXA7/BAD/SNAI2/MSH2/CASP8/PREX1/RET/TFF1/CDKN2A/DIABLO/MACC1/IDH3A/SQSTM1/SRSF1
## GO:0009055
## ID Description Count GeneRatio
## GO:0000003 GO:0000003 reproduction 55 55/199
## GO:0002376 GO:0002376 immune system process 93 93/199
## GO:0008152 GO:0008152 metabolic process 174 174/199
## GO:0009987 GO:0009987 cellular process 197 197/199
## GO:0016032 GO:0016032 viral process 16 16/199
## GO:0022414 GO:0022414 reproductive process 54 54/199
## geneID
## GO:0000003 DIRAS3/CDKN1B/KDR/IGFBP2/BCL2L11/SRC/AKT1/RAD51/IGF1R/RB1/ESR1/PTEN/PIK3CA/GATA3/AXL/ATM/NOTCH1/ITGA2/STK11/BRCA2/EGFR/CCNE1/MTOR/PCNA/BAK1/SMAD4/CTNNB1/SMAD1/STAT3/FOXO3/GSK3A/PARK7/BCL2/CDK1/CTNNA1/RAD50/AR/BCL2L1/TP63/MSH6/KIT/PTCH1/RPS6KB1/MYH9/COL6A1/PGR/ERCC1/BAX/CCNE2/PTGS2/ERRFI1/PARP1/CASP3/MSH2/CASP8
## GO:0002376 MAPK14/ERBB2/G6PD/MAPK8/PRKCD/IGFBP2/FN1/BCL2L11/SRC/AKT1/TP53/IGF1R/RBM15/BECN1/RB1/ESR1/PIK3CA/CDKN1A/GATA3/SMAD3/RAF1/AXL/ATM/MAPK1/TP53BP1/NEK7/BIRC2/NOTCH1/MAPK9/YWHAZ/XRCC5/ITGA2/BAP1/STK11/ADAR/MTOR/SERPINE1/YWHAE/MAPK3/TSC1/BAK1/PECAM1/CTNNB1/LCN2/NFE2L2/MAPT/PRKCA/STAT3/FOXO3/PTK2/PARK7/BCL2/ETS1/MS4A1/LCK/NFKB1/MYC/CAV1/PIK3R1/PRDX1/XBP1/GAPDH/MSH6/KIT/BRAF/RPS6KB1/MYH9/MAP2K1/XIAP/NDRG1/GAB2/PIK3R2/ANXA1/EZH2/ERCC1/BAX/BID/ARID1A/TFRC/HSPA1A/PARP1/CASP3/SYK/RPTOR/SETD2/BAD/SNAI2/MSH2/CASP8/PREX1/RET/CHGA/SQSTM1
## GO:0008152 DIRAS3/MAPK14/YAP1/CDKN1B/ERBB2/G6PD/KDR/ERBB3/AKT1S1/MAPK8/PRKCD/EIF4EBP1/RPS6KA1/FN1/ASNS/SRC/AKT2/AKT3/AKT1/RAD51/MET/TP53/IGF1R/RBM15/BECN1/RB1/ESR1/PTEN/PIK3CA/CDKN1A/GATA3/SMAD3/RAF1/EIF4G1/AXL/ATM/MAPK1/TP53BP1/NEK7/BIRC2/NOTCH1/MAPK9/YWHAZ/XRCC5/ITGA2/CASP7/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/FASN/EEF2/MTOR/SERPINE1/YWHAE/MAPK3/INPP4B/PCNA/ACVRL1/TSC1/CHEK2/BAK1/SMAD4/TSC2/PECAM1/CTNNB1/LCN2/YBX1/RPS6/NFE2L2/MAPT/CDH3/PRKCA/PDCD4/SHC1/TTF1/SMAD1/RICTOR/JUN/EIF4E/CHEK1/CDH1/STAT3/ACACA/WWTR1/FOXO3/GSK3B/GSK3A/PTK2/PARK7/TGM2/BCL2/RAB11B/ETS1/ACACB/CDK1/EEF2K/LCK/KEAP1/E2F1/XRCC1/NFKB1/RAD50/MYC/IRS1/VHL/CCND1/CAV1/PIK3R1/AR/PRDX1/NCOA3/XBP1/TP63/GAPDH/TYMS/MSH6/KIT/CCNB1/BRAF/NF2/DVL3/PTCH1/NRG1/ARAF/RPS6KB1/MYH9/NOTCH3/KRAS/PDK1/MAP2K1/PRKAA1/FOXM1/COL6A1/STAT5A/XIAP/PGR/YWHAB/PIK3R2/ANXA1/EZH2/ERCC1/BAX/BID/ARID1A/TFRC/HSPA1A/CCNE2/PTGS2/ERRFI1/PARP1/RBM3/CASP9/CASP3/NAPSA/SYK/RPTOR/SETD2/ANXA7/BAD/SNAI2/MSH2/CASP8/PREX1/RET/TFF1/CDKN2A/DIABLO/MACC1/IDH3A/SQSTM1/SRSF1
## GO:0009987 DIRAS3/MAPK14/YAP1/CDKN1B/ERBB2/G6PD/KDR/ERBB3/AKT1S1/MAPK8/PRKCD/EIF4EBP1/IGFBP2/RPS6KA1/FN1/BCL2L11/ASNS/SRC/AKT2/AKT3/AKT1/CDH2/RAD51/MET/NRAS/TP53/CLDN7/IGF1R/RBM15/BECN1/RB1/ESR1/PTEN/PIK3CA/CDKN1A/GATA3/PEA15/SMAD3/RAF1/EIF4G1/AXL/ATM/MAPK1/TP53BP1/NEK7/BIRC2/NOTCH1/MAPK9/YWHAZ/VASP/XRCC5/ITGA2/CASP7/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/FASN/EEF2/MTOR/SERPINE1/YWHAE/MAPK3/INPP4B/PCNA/ACVRL1/TSC1/CHEK2/BAK1/SMAD4/TSC2/PECAM1/CTNNB1/LCN2/YBX1/RPS6/NFE2L2/MAPT/CDH3/PRKCA/ANLN/PDCD4/SHC1/TTF1/SMAD1/STMN1/RICTOR/JUN/EIF4E/CHEK1/CDH1/STAT3/ACACA/WWTR1/FOXO3/GSK3B/GSK3A/PTK2/PARK7/TGM2/BCL2/PRRT2/RAB11B/RAB11A/ETS1/ACACB/CDK1/MS4A1/EEF2K/LCK/KEAP1/E2F1/XRCC1/CTNNA1/NFKB1/RAD50/MYC/IRS1/VHL/CCND1/CAV1/PIK3R1/AR/PRDX1/NCOA3/XBP1/BCL2L1/TP63/GAPDH/TYMS/MSH6/KIT/CCNB1/BRAF/TUBA1B/MYH11/NF2/DVL3/PTCH1/NRG1/KRT5/ARAF/RPS6KB1/MYH9/NOTCH3/KRAS/PDK1/MAP2K1/PRKAA1/FOXM1/COL6A1/STAT5A/XIAP/NDRG1/PGR/GAB2/YWHAB/PIK3R2/ANXA1/EZH2/RAB25/ERCC1/BAX/BID/ARID1A/TFRC/HSPA1A/PXN/CCNE2/PTGS2/ERRFI1/SYP/PARP1/RBM3/CASP9/CASP3/SYK/RPTOR/SETD2/ANXA7/BAD/SNAI2/MSH2/CASP8/PREX1/RET/TFF1/CDKN2A/DIABLO/MACC1/CHGA/IDH3A/SQSTM1/KCNJ13/SRSF1
## GO:0016032 AKT1/TP53/BECN1/AXL/NOTCH1/ITGA2/ADAR/EGFR/JUN/GSK3B/GSK3A/BCL2/CDK1/CAV1/TFRC/HSPA1A
## GO:0022414 DIRAS3/CDKN1B/KDR/IGFBP2/BCL2L11/SRC/AKT1/RAD51/IGF1R/RB1/ESR1/PTEN/PIK3CA/GATA3/AXL/ATM/NOTCH1/ITGA2/STK11/BRCA2/EGFR/CCNE1/MTOR/PCNA/BAK1/SMAD4/CTNNB1/SMAD1/FOXO3/GSK3A/PARK7/BCL2/CDK1/CTNNA1/RAD50/AR/BCL2L1/TP63/MSH6/KIT/PTCH1/RPS6KB1/MYH9/COL6A1/PGR/ERCC1/BAX/CCNE2/PTGS2/ERRFI1/PARP1/CASP3/MSH2/CASP8
## ID Description Count GeneRatio
## GO:0032991 GO:0032991 protein-containing complex 129 129/199
## GO:0044423 GO:0044423 virion component 0 0/199
## GO:0110165 GO:0110165 cellular anatomical entity 198 198/199
## geneID
## GO:0032991 YAP1/CDKN1B/ERBB2/KDR/ERBB3/AKT1S1/FN1/BCL2L11/AKT1/CDH2/RAD51/MET/TP53/IGF1R/RBM15/BECN1/RB1/ESR1/PIK3CA/CDKN1A/GATA3/PEA15/SMAD3/EIF4G1/AXL/ATM/TP53BP1/BIRC2/NOTCH1/XRCC5/ITGA2/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/EEF2/MTOR/SERPINE1/PCNA/ACVRL1/TSC1/BAK1/SMAD4/TSC2/PECAM1/CTNNB1/YBX1/RPS6/NFE2L2/MAPT/CDH3/PRKCA/SHC1/SMAD1/RICTOR/JUN/EIF4E/CHEK1/CDH1/STAT3/WWTR1/FOXO3/GSK3B/GSK3A/PARK7/TGM2/BCL2/RAB11A/ETS1/ACACB/CDK1/KEAP1/E2F1/XRCC1/CTNNA1/NFKB1/RAD50/MYC/IRS1/CCND1/CAV1/PIK3R1/AR/NCOA3/XBP1/BCL2L1/TP63/GAPDH/MSH6/KIT/CCNB1/MYH11/DVL3/MYH9/NOTCH3/PDK1/PRKAA1/FOXM1/COL6A1/STAT5A/PGR/PIK3R2/EZH2/ERCC1/BAX/ARID1A/TFRC/HSPA1A/PXN/CCNE2/PTGS2/PARP1/RBM3/CASP9/CASP3/SYK/RPTOR/BAD/SNAI2/MSH2/CASP8/RET/CDKN2A/DIABLO/IDH3A/KCNJ13/SRSF1
## GO:0044423
## GO:0110165 DIRAS3/MAPK14/YAP1/CDKN1B/ERBB2/G6PD/KDR/ERBB3/AKT1S1/MAPK8/PRKCD/EIF4EBP1/IGFBP2/RPS6KA1/FN1/BCL2L11/ASNS/SRC/AKT2/AKT3/AKT1/CDH2/RAD51/MET/NRAS/TP53/CLDN7/IGF1R/RBM15/BECN1/RB1/ESR1/PTEN/PIK3CA/CDKN1A/GATA3/PEA15/SMAD3/RAF1/EIF4G1/AXL/ATM/MAPK1/TP53BP1/NEK7/BIRC2/NOTCH1/MAPK9/YWHAZ/VASP/XRCC5/ITGA2/CASP7/BAP1/STK11/ADAR/BRCA2/EGFR/CCNE1/FASN/EEF2/MTOR/SERPINE1/YWHAE/MAPK3/INPP4B/PCNA/ACVRL1/TSC1/CHEK2/BAK1/SMAD4/TSC2/PECAM1/CTNNB1/LCN2/YBX1/RPS6/NFE2L2/MAPT/CDH3/PRKCA/ANLN/PDCD4/SHC1/TTF1/SMAD1/STMN1/RICTOR/JUN/EIF4E/CHEK1/CDH1/STAT3/ACACA/WWTR1/FOXO3/GSK3B/GSK3A/PTK2/PARK7/TGM2/BCL2/PRRT2/RAB11B/RAB11A/ETS1/ACACB/CDK1/MS4A1/EEF2K/LCK/KEAP1/E2F1/XRCC1/CTNNA1/NFKB1/RAD50/MYC/IRS1/VHL/CCND1/CAV1/PIK3R1/AR/PRDX1/NCOA3/XBP1/BCL2L1/TP63/GAPDH/TYMS/MSH6/KIT/CCNB1/BRAF/TUBA1B/MYH11/NF2/DVL3/PTCH1/NRG1/KRT5/ARAF/RPS6KB1/MYH9/NOTCH3/KRAS/PDK1/MAP2K1/PRKAA1/FOXM1/COL6A1/STAT5A/XIAP/NDRG1/PGR/GAB2/YWHAB/PIK3R2/ANXA1/EZH2/RAB25/ERCC1/BAX/BID/ARID1A/TFRC/HSPA1A/PXN/CCNE2/PTGS2/ERRFI1/SYP/PARP1/RBM3/CASP9/CASP3/NAPSA/SYK/RPTOR/SETD2/ANXA7/BAD/SNAI2/MSH2/CASP8/PREX1/RET/TFF1/CDKN2A/DIABLO/MACC1/CHGA/IDH3A/SQSTM1/KCNJ13/SRSF1barplot(ggo_MF[[1]], title = "groupGO, Molecular Function, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ggo_MF[[2]], title = "groupGO, Molecular Function, \n All Selected Genes, Cox Regression Glmnet")
barplot(ggo_MF[[3]], title = "groupGO, Molecular Function, \n All Selected Genes, Squeezy")
barplot(ggo_MF[[4]], title = "groupGO, Molecular Function, \n All Selected Genes, Globaltest")
barplot(ggo_MF[[5]], title = "groupGO, Molecular Function, \n All Selected Genes, FABIA")
barplot(ggo_MF[[6]], title = "groupGO, Molecular Function, \n All Selected Genes, MOFA")
barplot(ggo_MF[[7]], title = "groupGO, Molecular Function, \n All Selected Genes, MFA")
barplot(ggo_MF[[8]], title = "groupGO, Molecular Function, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ggo_MF[[9]], title = "groupGO, Molecular Function, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ggo_MF[[10]], title = "groupGO, Molecular Function, \n All Selected Genes, Gaussian Graphical Models")
barplot(ggo_MF[[11]], title = "groupGO, Molecular Function, \n All Genes in ACC Dataset")
barplot(ggo_BP[[1]], title = "groupGO, Biological Process, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ggo_BP[[2]], title = "groupGO, Biological Process, \n All Selected Genes, Cox Regression Glmnet")
barplot(ggo_BP[[3]], title = "groupGO, Biological Process, \n All Selected Genes, Squeezy")
barplot(ggo_BP[[4]], title = "groupGO, Biological Process, \n All Selected Genes, Globaltest")
barplot(ggo_BP[[5]], title = "groupGO, Biological Process, \n All Selected Genes, FABIA")
barplot(ggo_BP[[6]], title = "groupGO, Biological Process, \n All Selected Genes, MOFA")
barplot(ggo_BP[[7]], title = "groupGO, Biological Process, \n All Selected Genes, MFA")
barplot(ggo_BP[[8]], title = "groupGO, Biological Process, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ggo_BP[[9]], title = "groupGO, Biological Process, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ggo_BP[[10]], title = "groupGO, Biological Process, \n All Selected Genes, Gaussian Graphical Models")
barplot(ggo_BP[[11]], title = "groupGO, Biological Process, \n All Genes in ACC Dataset")
barplot(ggo_CC[[1]], title = "groupGO, Cellular Component, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ggo_CC[[2]], title = "groupGO, Cellular Component, \n All Selected Genes, Cox Regression Glmnet")
barplot(ggo_CC[[3]], title = "groupGO, Cellular Component, \n All Selected Genes, Squeezy")
barplot(ggo_CC[[4]], title = "groupGO, Cellular Component, \n All Selected Genes, Globaltest")
barplot(ggo_CC[[5]], title = "groupGO, Cellular Component, \n All Selected Genes, FABIA")
barplot(ggo_CC[[6]], title = "groupGO, Cellular Component, \n All Selected Genes, MOFA")
barplot(ggo_CC[[7]], title = "groupGO, Cellular Component, \n All Selected Genes, MFA")
barplot(ggo_CC[[8]], title = "groupGO, Cellular Component, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ggo_CC[[9]], title = "groupGO, Cellular Component, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ggo_CC[[10]], title = "groupGO, Cellular Component, \n All Selected Genes, Gaussian Graphical Models")
barplot(ggo_CC[[11]], title = "groupGO, Cellular Component, \n All Genes in ACC Dataset")
B. GO Over-Representation
ego_MF <- list()#GO enrichment of a geneset for Molecular Function
ego_BP <- list()#GO enrichment of a geneset for Biological Process
ego_CC <- list()#GO enrichment of a geneset for Cellular Component
for(z in 1:length(geneNames)){
print(z)
input <- geneNames[[z]]
ego_MF[[z]] <- enrichGO(
gene = input,
OrgDb = org.Hs.eg.db,
ont = "MF",
pAdjustMethod = "BH",
keyType="SYMBOL",
pvalueCutoff = 0.05,
qvalueCutoff = 0.05,
minGSSize = 2,
readable = TRUE)
ego_BP[[z]] <- enrichGO(
gene = input,
OrgDb = org.Hs.eg.db,
ont = "BP",
pAdjustMethod = "BH",
keyType="SYMBOL",
pvalueCutoff = 0.05,
qvalueCutoff = 0.05,
minGSSize = 2,
readable = TRUE)
ego_CC[[z]] <- enrichGO(
gene = input,
OrgDb = org.Hs.eg.db,
ont = "CC",
pAdjustMethod = "BH",
keyType="SYMBOL",
pvalueCutoff = 0.05,
qvalueCutoff = 0.05,
minGSSize = 2,
readable = TRUE)
}## [1] 1
## [1] 2
## [1] 3
## [1] 4
## [1] 5
## [1] 6
## [1] 7
## [1] 8
## [1] 9
## [1] 10
## [1] 11for(z in 1:length(geneNames)){
print(head(ego_MF[[z]]))
print(head(ego_BP[[z]]))
print(head(ego_CC[[z]]))
}## ID Description GeneRatio
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 17/92
## GO:0004674 GO:0004674 protein serine/threonine kinase activity 16/92
## GO:0045296 GO:0045296 cadherin binding 14/92
## GO:0043125 GO:0043125 ErbB-3 class receptor binding 4/92
## GO:0106310 GO:0106310 protein serine kinase activity 14/92
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 13/92
## BgRatio pvalue p.adjust qvalue
## GO:0140297 478/18522 1.787075e-10 6.527056e-08 3.185892e-08
## GO:0004674 427/18522 3.057169e-10 6.527056e-08 3.185892e-08
## GO:0045296 333/18522 9.998688e-10 1.423147e-07 6.946457e-08
## GO:0043125 5/18522 2.839009e-09 2.515155e-07 1.227661e-07
## GO:0106310 363/18522 3.038054e-09 2.515155e-07 1.227661e-07
## GO:0031625 305/18522 3.534176e-09 2.515155e-07 1.227661e-07
## geneID
## GO:0140297 AR/RB1/E2F1/MYC/GSK3B/MAPK3/JUN/TP53/CTNNB1/YAP1/PCNA/SMAD4/ETS1/BCL2/YWHAZ/STAT3/PARP1
## GO:0004674 AKT1/CHEK1/CDK1/RAF1/AKT3/GSK3B/MAPK1/STK11/MAPK3/ACVRL1/EEF2K/PRKAA1/ATM/MAPK9/PIK3CA/PRKCA
## GO:0045296 FASN/EEF2/KDR/RAB11B/YWHAB/CTNNB1/CDH2/NOTCH3/ANXA1/YWHAZ/PRDX1/MYH9/CTNNA1/NDRG1
## GO:0043125 ERBB2/PIK3R1/ERBB3/NRG1
## GO:0106310 AKT1/CHEK1/CDK1/RAF1/AKT3/GSK3B/MAPK1/STK11/MAPK3/PRKAA1/ATM/MAPK9/PIK3CA/PRKCA
## GO:0031625 RB1/TUBA1B/BECN1/ERBB3/GSK3B/CDKN1A/JUN/TP53/CTNNB1/SQSTM1/BCL2/YWHAZ/PARP1
## Count
## GO:0140297 17
## GO:0004674 16
## GO:0045296 14
## GO:0043125 4
## GO:0106310 14
## GO:0031625 13
## ID Description GeneRatio
## GO:0048732 GO:0048732 gland development 25/93
## GO:0097193 GO:0097193 intrinsic apoptotic signaling pathway 22/93
## GO:0050673 GO:0050673 epithelial cell proliferation 24/93
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 21/93
## GO:0104004 GO:0104004 cellular response to environmental stimulus 21/93
## GO:0051402 GO:0051402 neuron apoptotic process 20/93
## BgRatio pvalue p.adjust qvalue
## GO:0048732 449/18888 8.816508e-20 3.546881e-16 1.522008e-16
## GO:0097193 319/18888 2.020410e-19 4.064054e-16 1.743933e-16
## GO:0050673 482/18888 7.053999e-18 7.922136e-15 3.399480e-15
## GO:0071214 334/18888 9.846055e-18 7.922136e-15 3.399480e-15
## GO:0104004 334/18888 9.846055e-18 7.922136e-15 3.399480e-15
## GO:0051402 292/18888 1.223043e-17 8.200501e-15 3.518930e-15
## geneID
## GO:0048732 NOTCH1/CCND1/AKT1/AR/FASN/SRSF1/BCL2L11/RAF1/XBP1/ITGA2/MAPK1/STK11/MAPK3/BAX/CTNNB1/ATM/PCNA/SMAD4/NRG1/PGR/SNAI2/BCL2/PIK3CA/TGM2/TYMS
## GO:0097193 AKT1/BCL2L1/PIK3R1/BECN1/E2F1/MYC/BCL2L11/XBP1/MSH6/CDKN1A/STK11/BAX/CASP9/PDK1/TP53/CTNNB1/ATM/SNAI2/BCL2/BAK1/CASP3/PARP1
## GO:0050673 NOTCH1/ERBB2/CCND1/AKT1/BCL2L1/AR/RB1/MYC/RAF1/XBP1/AKT3/KDR/CDKN1A/MAPK1/STK11/ACVRL1/BAX/CTNNB1/YAP1/PGR/SNAI2/BAK1/STAT3/PRKCA
## GO:0071214 BCL2L1/PIK3R1/CHEK1/IGF1R/MYC/ITGA2/CDKN1A/STK11/MAPK3/RAB11B/BAX/CASP9/TP53/YAP1/ATM/PCNA/SNAI2/BAK1/CASP3/PARP1/PIK3CA
## GO:0104004 BCL2L1/PIK3R1/CHEK1/IGF1R/MYC/ITGA2/CDKN1A/STK11/MAPK3/RAB11B/BAX/CASP9/TP53/YAP1/ATM/PCNA/SNAI2/BAK1/CASP3/PARP1/PIK3CA
## GO:0051402 KRAS/CCND1/BCL2L1/RB1/XIAP/ERBB3/FOXO3/BCL2L11/GSK3B/KDR/BAX/CASP9/TP53/CTNNB1/ATM/BCL2/AXL/CASP3/PARP1/PIK3CA
## Count
## GO:0048732 25
## GO:0097193 22
## GO:0050673 24
## GO:0071214 21
## GO:0104004 21
## GO:0051402 20
## ID
## GO:0097136 GO:0097136
## GO:0061695 GO:0061695
## GO:1902911 GO:1902911
## GO:0005741 GO:0005741
## GO:0031968 GO:0031968
## GO:0019867 GO:0019867
## Description
## GO:0097136 Bcl-2 family protein complex
## GO:0061695 transferase complex, transferring phosphorus-containing groups
## GO:1902911 protein kinase complex
## GO:0005741 mitochondrial outer membrane
## GO:0031968 organelle outer membrane
## GO:0019867 outer membrane
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0097136 5/93 10/19894 4.953734e-10 1.491074e-07 8.864577e-08
## GO:0061695 12/93 308/19894 2.083761e-08 3.136061e-06 1.864418e-06
## GO:1902911 9/93 150/19894 3.472195e-08 3.483769e-06 2.071134e-06
## GO:0005741 10/93 219/19894 7.752987e-08 5.834123e-06 3.468441e-06
## GO:0031968 10/93 248/19894 2.467527e-07 1.333202e-05 7.926011e-06
## GO:0019867 10/93 250/19894 2.657545e-07 1.333202e-05 7.926011e-06
## geneID
## GO:0097136 BCL2L1/BCL2L11/BAX/BCL2/BAK1
## GO:0061695 CCND1/RB1/PIK3R1/IGF1R/CDK1/BECN1/CDKN1A/STK11/PRKAA1/PCNA/PIK3CA/IRS1
## GO:1902911 CCND1/RB1/IGF1R/CDK1/CDKN1A/STK11/PRKAA1/PCNA/IRS1
## GO:0005741 KRAS/BCL2L1/BECN1/FOXO3/BCL2L11/RAF1/BAX/PGR/BCL2/BAK1
## GO:0031968 KRAS/BCL2L1/BECN1/FOXO3/BCL2L11/RAF1/BAX/PGR/BCL2/BAK1
## GO:0019867 KRAS/BCL2L1/BECN1/FOXO3/BCL2L11/RAF1/BAX/PGR/BCL2/BAK1
## Count
## GO:0097136 5
## GO:0061695 12
## GO:1902911 9
## GO:0005741 10
## GO:0031968 10
## GO:0019867 10
## ID Description
## GO:0004674 GO:0004674 protein serine/threonine kinase activity
## GO:0106310 GO:0106310 protein serine kinase activity
## GO:0004707 GO:0004707 MAP kinase activity
## GO:0035173 GO:0035173 histone kinase activity
## GO:0004712 GO:0004712 protein serine/threonine/tyrosine kinase activity
## GO:0030544 GO:0030544 Hsp70 protein binding
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0004674 7/18 427/18522 8.420101e-08 9.430513e-06 4.697530e-06
## GO:0106310 6/18 363/18522 8.271790e-07 4.632202e-05 2.307394e-05
## GO:0004707 2/18 16/18522 1.061813e-04 3.964103e-03 1.974600e-03
## GO:0035173 2/18 23/18522 2.229651e-04 6.243024e-03 3.109777e-03
## GO:0004712 2/18 43/18522 7.866924e-04 1.762191e-02 8.777831e-03
## GO:0030544 2/18 51/18522 1.105678e-03 2.063932e-02 1.028086e-02
## geneID Count
## GO:0004674 AKT1/MAPK9/MAPK3/CHEK1/CDK1/EEF2K/PRKCD 7
## GO:0106310 AKT1/MAPK9/MAPK3/CHEK1/CDK1/PRKCD 6
## GO:0004707 MAPK9/MAPK3 2
## GO:0035173 CHEK1/CDK1 2
## GO:0004712 AKT1/MAPK9 2
## GO:0030544 CDK1/TFRC 2
## ID Description
## GO:0051054 GO:0051054 positive regulation of DNA metabolic process
## GO:1900182 GO:1900182 positive regulation of protein localization to nucleus
## GO:0018105 GO:0018105 peptidyl-serine phosphorylation
## GO:1900180 GO:1900180 regulation of protein localization to nucleus
## GO:0018209 GO:0018209 peptidyl-serine modification
## GO:0034614 GO:0034614 cellular response to reactive oxygen species
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0051054 7/18 301/18888 6.666566e-09 1.043318e-05 4.329759e-06
## GO:1900182 5/18 94/18888 2.231785e-08 1.746372e-05 7.247428e-06
## GO:0018105 6/18 282/18888 1.676932e-07 6.086976e-05 2.526090e-05
## GO:1900180 5/18 144/18888 1.900209e-07 6.086976e-05 2.526090e-05
## GO:0018209 6/18 294/18888 2.143839e-07 6.086976e-05 2.526090e-05
## GO:0034614 5/18 151/18888 2.407405e-07 6.086976e-05 2.526090e-05
## geneID Count
## GO:0051054 AKT1/RAD51/MAPK3/CDK1/FOXM1/TFRC/PRKCD 7
## GO:1900182 AKT1/CDK1/TFRC/PRKCD/WWTR1 5
## GO:0018105 AKT1/MAPK9/CDK1/RET/TFRC/PRKCD 6
## GO:1900180 AKT1/CDK1/TFRC/PRKCD/WWTR1 5
## GO:0018209 AKT1/MAPK9/CDK1/RET/TFRC/PRKCD 6
## GO:0034614 AKT1/MAPK9/MAPK3/CDK1/PRKCD 5
## ID Description GeneRatio BgRatio
## GO:0000781 GO:0000781 chromosome, telomeric region 3/18 173/19894
## GO:0005769 GO:0005769 early endosome 4/18 428/19894
## GO:0016323 GO:0016323 basolateral plasma membrane 3/18 255/19894
## GO:0016328 GO:0016328 lateral plasma membrane 2/18 68/19894
## GO:0097122 GO:0097122 cyclin A2-CDK1 complex 1/18 2/19894
## GO:0097125 GO:0097125 cyclin B1-CDK1 complex 1/18 2/19894
## pvalue p.adjust qvalue geneID Count
## GO:0000781 0.0004790537 0.02601912 0.02015384 RAD51/CHEK1/CDK1 3
## GO:0005769 0.0005087747 0.02601912 0.02015384 MAPK3/RET/TFRC/ANXA1 4
## GO:0016323 0.0014728354 0.02601912 0.02015384 TFRC/CLDN7/ANXA1 3
## GO:0016328 0.0017001738 0.02601912 0.02015384 CLDN7/ANXA1 2
## GO:0097122 0.0018088176 0.02601912 0.02015384 CDK1 1
## GO:0097125 0.0018088176 0.02601912 0.02015384 CDK1 1
## ID
## GO:0004314 GO:0004314
## GO:0004315 GO:0004315
## GO:0004316 GO:0004316
## GO:0004345 GO:0004345
## GO:0004998 GO:0004998
## GO:0008659 GO:0008659
## Description
## GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity
## GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
## GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
## GO:0004345 glucose-6-phosphate dehydrogenase activity
## GO:0004998 transferrin receptor activity
## GO:0008659 (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
## GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
## GO:0004314 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 FASN 1
## GO:0004315 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 FASN 1
## GO:0004316 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 FASN 1
## GO:0004345 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 G6PD 1
## GO:0004998 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 TFRC 1
## GO:0008659 1/6 2/18522 0.0006477907 0.003240407 0.0006541557 FASN 1
## ID
## GO:0010039 GO:0010039
## GO:0044403 GO:0044403
## GO:0006953 GO:0006953
## GO:0002204 GO:0002204
## GO:0002208 GO:0002208
## GO:0045190 GO:0045190
## Description
## GO:0010039 response to iron ion
## GO:0044403 biological process involved in symbiotic interaction
## GO:0006953 acute-phase response
## GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
## GO:0002208 somatic diversification of immunoglobulins involved in immune response
## GO:0045190 isotype switching
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0010039 2/6 28/18888 3.167154e-05 0.00792854 0.003156436
## GO:0044403 3/6 311/18888 8.523132e-05 0.00792854 0.003156436
## GO:0006953 2/6 47/18888 9.033104e-05 0.00792854 0.003156436
## GO:0002204 2/6 53/18888 1.150515e-04 0.00792854 0.003156436
## GO:0002208 2/6 53/18888 1.150515e-04 0.00792854 0.003156436
## GO:0045190 2/6 53/18888 1.150515e-04 0.00792854 0.003156436
## geneID Count
## GO:0010039 G6PD/TFRC 2
## GO:0044403 FN1/FASN/TFRC 3
## GO:0006953 FN1/TFRC 2
## GO:0002204 MSH6/TFRC 2
## GO:0002208 MSH6/TFRC 2
## GO:0045190 MSH6/TFRC 2
## ID Description GeneRatio BgRatio pvalue
## GO:0042470 GO:0042470 melanosome 2/6 112/19894 0.0004642992
## GO:0048770 GO:0048770 pigment granule 2/6 112/19894 0.0004642992
## GO:0032301 GO:0032301 MutSalpha complex 1/6 2/19894 0.0006031211
## GO:0072562 GO:0072562 blood microparticle 2/6 144/19894 0.0007657506
## GO:0042587 GO:0042587 glycogen granule 1/6 6/19894 0.0018084541
## GO:0005577 GO:0005577 fibrinogen complex 1/6 8/19894 0.0024106661
## p.adjust qvalue geneID Count
## GO:0042470 0.007466069 0.004030266 FASN/TFRC 2
## GO:0048770 0.007466069 0.004030266 FASN/TFRC 2
## GO:0032301 0.007466069 0.004030266 MSH6 1
## GO:0072562 0.007466069 0.004030266 FN1/TFRC 2
## GO:0042587 0.013430854 0.007250124 FASN 1
## GO:0005577 0.013430854 0.007250124 FN1 1
## ID Description GeneRatio
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 16/84
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 12/84
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 11/84
## GO:0019207 GO:0019207 kinase regulator activity 10/84
## GO:0004674 GO:0004674 protein serine/threonine kinase activity 12/84
## GO:0043125 GO:0043125 ErbB-3 class receptor binding 3/84
## BgRatio pvalue p.adjust qvalue
## GO:0140297 478/18522 3.841091e-10 1.582530e-07 7.196992e-08
## GO:0044389 324/18522 2.453935e-08 5.055106e-06 2.298950e-06
## GO:0031625 305/18522 1.287463e-07 1.768116e-05 8.040997e-06
## GO:0019207 270/18522 3.923050e-07 4.015344e-05 1.826089e-05
## GO:0004674 427/18522 4.872991e-07 4.015344e-05 1.826089e-05
## GO:0043125 5/18522 8.939725e-07 6.138611e-05 2.791704e-05
## geneID
## GO:0140297 RB1/ETS1/ARID1A/MYC/VHL/BCL2/TP53/YAP1/YWHAZ/STAT3/PARP1/CTNNB1/MAPK3/NCOA3/JUN/AR
## GO:0044389 RB1/BID/CDKN1A/TUBA1B/ERBB3/BCL2/TP53/YWHAZ/PARP1/CTNNB1/JUN/CCNB1
## GO:0031625 RB1/BID/CDKN1A/TUBA1B/ERBB3/BCL2/TP53/YWHAZ/PARP1/CTNNB1/JUN
## GO:0019207 CDKN1A/CCND1/PIK3R1/ERBB3/CASP3/PIK3CA/YWHAB/AKT1/CCNB1/RICTOR
## GO:0004674 MAPK8/CHEK1/PIK3CA/PRKCA/MAPK3/RAF1/MAPK9/PRKAA1/AKT1/CDK1/EEF2K/ACVRL1
## GO:0043125 PIK3R1/ERBB3/ERBB2
## Count
## GO:0140297 16
## GO:0044389 12
## GO:0031625 11
## GO:0019207 10
## GO:0004674 12
## GO:0043125 3
## ID Description GeneRatio
## GO:0009411 GO:0009411 response to UV 16/85
## GO:0071496 GO:0071496 cellular response to external stimulus 19/85
## GO:0051402 GO:0051402 neuron apoptotic process 18/85
## GO:0097305 GO:0097305 response to alcohol 17/85
## GO:0097193 GO:0097193 intrinsic apoptotic signaling pathway 18/85
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 18/85
## BgRatio pvalue p.adjust qvalue
## GO:0009411 154/18888 8.365458e-18 3.010728e-14 1.413322e-14
## GO:0071496 335/18888 4.735674e-16 8.521846e-13 4.000398e-13
## GO:0051402 292/18888 7.163738e-16 8.594098e-13 4.034316e-13
## GO:0097305 259/18888 1.759118e-15 1.582767e-12 7.429961e-13
## GO:0097193 319/18888 3.361536e-15 2.419634e-12 1.135845e-12
## GO:0071214 334/18888 7.468248e-15 3.839746e-12 1.802487e-12
## geneID
## GO:0009411 MAPK8/CDKN1A/MYC/CCND1/PIK3R1/BCL2/BAK1/CASP3/TP53/PARP1/PRKAA1/AKT1/MSH6/CASP9/MSH2/ERCC1
## GO:0071496 MAPK8/CDKN1A/CHEK1/IGF1R/FOXO3/BCL2/AXL/BAK1/TP53/YWHAZ/MAPK3/EIF4G1/PRKAA1/TSC2/NFKB1/RICTOR/ASNS/XBP1/TSC1
## GO:0051402 RB1/XIAP/BID/CCND1/ERBB3/FOXO3/BCL2/AXL/CASP3/BCL2L11/TP53/PARP1/CTNNB1/PIK3CA/CASP9/BCL2L1/G6PD/MSH2
## GO:0097305 CDKN1A/IGF1R/FOXO3/ACACA/BAK1/PARP1/CTNNB1/TYMS/CLDN7/CTNNA1/EIF4G1/PRKAA1/AKT1/CDK1/RAD51/BCL2L1/G6PD
## GO:0097193 BID/CDKN1A/MYC/PIK3R1/BCL2/BAK1/CASP3/BCL2L11/TP53/PARP1/CTNNB1/PDK1/AKT1/MSH6/CASP9/BCL2L1/MSH2/XBP1
## GO:0071214 MAPK8/CDKN1A/MYC/PIK3R1/CHEK1/IGF1R/BAK1/CASP3/TP53/YAP1/PARP1/PIK3CA/MAPK3/RAD51/CASP9/BCL2L1/NFKB1/ERCC1
## Count
## GO:0009411 16
## GO:0071496 19
## GO:0051402 18
## GO:0097305 17
## GO:0097193 18
## GO:0071214 18
## ID
## GO:0097136 GO:0097136
## GO:1902911 GO:1902911
## GO:0061695 GO:0061695
## GO:0000307 GO:0000307
## GO:0000781 GO:0000781
## GO:0032301 GO:0032301
## Description
## GO:0097136 Bcl-2 family protein complex
## GO:1902911 protein kinase complex
## GO:0061695 transferase complex, transferring phosphorus-containing groups
## GO:0000307 cyclin-dependent protein kinase holoenzyme complex
## GO:0000781 chromosome, telomeric region
## GO:0032301 MutSalpha complex
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0097136 4/85 10/19894 6.390734e-08 1.853313e-05 1.130151e-05
## GO:1902911 8/85 150/19894 2.551783e-07 3.700085e-05 2.256313e-05
## GO:0061695 10/85 308/19894 7.673741e-07 7.417950e-05 4.523468e-05
## GO:0000307 5/85 56/19894 4.068739e-06 2.949836e-04 1.798811e-04
## GO:0000781 7/85 173/19894 9.292010e-06 5.389366e-04 3.286437e-04
## GO:0032301 2/85 2/19894 1.804163e-05 6.321121e-04 3.854622e-04
## geneID Count
## GO:0097136 BCL2/BAK1/BCL2L11/BCL2L1 4
## GO:1902911 RB1/CDKN1A/CCND1/IGF1R/IRS1/PRKAA1/CDK1/CCNB1 8
## GO:0061695 RB1/CDKN1A/CCND1/PIK3R1/IGF1R/PIK3CA/IRS1/PRKAA1/CDK1/CCNB1 10
## GO:0000307 RB1/CDKN1A/CCND1/CDK1/CCNB1 5
## GO:0000781 CHEK1/PARP1/CDK1/RAD51/EZH2/MSH2/ERCC1 7
## GO:0032301 MSH6/MSH2 2
## ID Description GeneRatio
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 21/100
## GO:0019902 GO:0019902 phosphatase binding 15/100
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 17/100
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 17/100
## GO:0019903 GO:0019903 protein phosphatase binding 12/100
## GO:0019207 GO:0019207 kinase regulator activity 15/100
## BgRatio pvalue p.adjust qvalue
## GO:0140297 478/18522 8.897902e-14 2.208867e-11 1.092469e-11
## GO:0019902 189/18522 9.184477e-14 2.208867e-11 1.092469e-11
## GO:0031625 305/18522 5.988911e-13 9.602220e-11 4.749101e-11
## GO:0044389 324/18522 1.584410e-12 1.905253e-10 9.423072e-11
## GO:0019903 142/18522 1.520189e-11 1.298375e-09 6.421548e-10
## GO:0019207 270/18522 1.619594e-11 1.298375e-09 6.421548e-10
## geneID
## GO:0140297 VHL/ETS1/STAT5A/YAP1/ESR1/BCL2/ARID1A/YWHAZ/NCOA3/CTNNB1/RB1/PARP1/MYC/GATA3/JUN/STAT3/E2F1/CDKN2A/SMAD3/MAPK3/AR
## GO:0019902 MAPK8/PTK2/MAPK1/MET/BCL2/CTNNB1/PIK3R1/CDH2/CDKN1B/MAPT/EGFR/STAT3/PXN/SMAD3/MAPK3
## GO:0031625 HSPA1A/CDKN1A/CASP8/BCL2/BID/YWHAZ/CTNNB1/RB1/TUBA1B/SQSTM1/PARP1/ERBB3/CDKN1B/JUN/CHEK2/EGFR/SMAD3
## GO:0044389 HSPA1A/CDKN1A/CASP8/BCL2/BID/YWHAZ/CTNNB1/RB1/TUBA1B/SQSTM1/PARP1/ERBB3/CDKN1B/JUN/CHEK2/EGFR/SMAD3
## GO:0019903 MAPK8/PTK2/MET/BCL2/CTNNB1/PIK3R1/CDH2/CDKN1B/MAPT/EGFR/STAT3/PXN
## GO:0019207 AKT1/CDKN1A/CCND1/PIK3R1/CCNE2/CASP3/PIK3CA/ERBB3/CDKN1B/EGFR/CAV1/CDKN2A/CCNE1/AKT1S1/RPTOR
## Count
## GO:0140297 21
## GO:0019902 15
## GO:0031625 17
## GO:0044389 17
## GO:0019903 12
## GO:0019207 15
## ID Description GeneRatio
## GO:0048732 GO:0048732 gland development 27/100
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 24/100
## GO:0104004 GO:0104004 cellular response to environmental stimulus 24/100
## GO:0062197 GO:0062197 cellular response to chemical stress 23/100
## GO:0051402 GO:0051402 neuron apoptotic process 22/100
## GO:0050673 GO:0050673 epithelial cell proliferation 25/100
## BgRatio pvalue p.adjust qvalue
## GO:0048732 449/18888 2.546673e-21 9.901464e-18 4.525035e-18
## GO:0071214 334/18888 9.051528e-21 1.173078e-17 5.361045e-18
## GO:0104004 334/18888 9.051528e-21 1.173078e-17 5.361045e-18
## GO:0062197 311/18888 3.366386e-20 3.272127e-17 1.495384e-17
## GO:0051402 292/18888 1.633773e-19 1.270422e-16 5.805912e-17
## GO:0050673 482/18888 3.311319e-18 2.145735e-15 9.806153e-16
## geneID
## GO:0048732 AKT1/ATM/STAT5A/CCND1/ITGA2/MAPK1/TGM2/ESR1/MET/BCL2/CTNNB1/SRSF1/FASN/BCL2L11/PIK3CA/GATA3/ERRFI1/CDKN1B/EZH2/EGFR/CAV1/BRCA2/RAF1/AKT2/SMAD3/MAPK3/AR
## GO:0071214 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/YAP1/ITGA2/IGF1R/CHEK1/PIK3R1/PARP1/MYC/CASP3/PIK3CA/GATA3/CHEK2/EGFR/BRCA2/CASP9/AKT2/BCL2L1/MAPK3/RPTOR
## GO:0104004 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/YAP1/ITGA2/IGF1R/CHEK1/PIK3R1/PARP1/MYC/CASP3/PIK3CA/GATA3/CHEK2/EGFR/BRCA2/CASP9/AKT2/BCL2L1/MAPK3/RPTOR
## GO:0062197 HSPA1A/AKT1/MTOR/MAPK8/FOXO3/ATM/MAPK1/G6PD/MET/PARP1/CASP3/PIK3CA/PRDX1/JUN/EZH2/MAPT/AXL/EGFR/CAV1/PXN/MAPK9/MAPK3/RPTOR
## GO:0051402 FOXO3/ATM/CASP8/KRAS/CCND1/G6PD/BCL2/XIAP/BID/CTNNB1/RB1/PARP1/CASP3/BCL2L11/PIK3CA/ERBB3/GATA3/AXL/CASP9/AKT2/BCL2L1/AKT1S1
## GO:0050673 AKT1/CDKN1A/NRAS/STAT5A/CCND1/YAP1/MAPK1/ESR1/BID/CTNNB1/RB1/MYC/GATA3/ERRFI1/CDKN1B/EGFR/CAV1/STAT3/BRCA2/RAF1/BCL2L1/SMAD3/PRKCA/RPTOR/AR
## Count
## GO:0048732 27
## GO:0071214 24
## GO:0104004 24
## GO:0062197 23
## GO:0051402 22
## GO:0050673 25
## ID Description GeneRatio BgRatio
## GO:0005925 GO:0005925 focal adhesion 16/100 421/19894
## GO:0030055 GO:0030055 cell-substrate junction 16/100 431/19894
## GO:0005741 GO:0005741 mitochondrial outer membrane 9/100 219/19894
## GO:0044853 GO:0044853 plasma membrane raft 7/100 113/19894
## GO:0031143 GO:0031143 pseudopodium 4/100 18/19894
## GO:0045121 GO:0045121 membrane raft 10/100 286/19894
## pvalue p.adjust qvalue
## GO:0005925 3.233184e-10 7.168686e-08 4.527591e-08
## GO:0030055 4.551547e-10 7.168686e-08 4.527591e-08
## GO:0005741 1.609700e-06 8.290411e-05 5.236049e-05
## GO:0044853 1.638486e-06 8.290411e-05 5.236049e-05
## GO:0031143 1.742181e-06 8.290411e-05 5.236049e-05
## GO:0045121 1.785485e-06 8.290411e-05 5.236049e-05
## geneID
## GO:0005925 HSPA1A/MYH9/KRAS/PTK2/ITGA2/MAPK1/TGM2/YWHAZ/CTNNB1/CDH2/SHC1/EGFR/CAV1/ANXA1/PXN/MAPK3
## GO:0030055 HSPA1A/MYH9/KRAS/PTK2/ITGA2/MAPK1/TGM2/YWHAZ/CTNNB1/CDH2/SHC1/EGFR/CAV1/ANXA1/PXN/MAPK3
## GO:0005741 MTOR/FOXO3/CASP8/KRAS/BCL2/BID/BCL2L11/RAF1/BCL2L1
## GO:0044853 MAPK1/IGF1R/CTNNB1/CDH2/IRS1/CAV1/MAPK3
## GO:0031143 MAPK1/RAB25/RAF1/MAPK3
## GO:0045121 MAPK1/IGF1R/GAB2/CTNNB1/CDH2/IRS1/MAPT/EGFR/CAV1/MAPK3
## Count
## GO:0005925 16
## GO:0030055 16
## GO:0005741 9
## GO:0044853 7
## GO:0031143 4
## GO:0045121 10
## ID Description GeneRatio
## GO:0019902 GO:0019902 phosphatase binding 16/123
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 22/123
## GO:0019207 GO:0019207 kinase regulator activity 16/123
## GO:0019887 GO:0019887 protein kinase regulator activity 15/123
## GO:0019903 GO:0019903 protein phosphatase binding 12/123
## GO:0004674 GO:0004674 protein serine/threonine kinase activity 18/123
## BgRatio pvalue p.adjust qvalue
## GO:0019902 189/18522 1.329406e-13 7.138909e-11 3.652367e-11
## GO:0140297 478/18522 7.298746e-13 1.959713e-10 1.002617e-10
## GO:0019207 270/18522 3.130805e-11 5.294880e-09 2.708936e-09
## GO:0019887 232/18522 3.944044e-11 5.294880e-09 2.708936e-09
## GO:0019903 142/18522 1.792141e-10 1.924759e-08 9.847343e-09
## GO:0004674 427/18522 4.517203e-10 3.562182e-08 1.822463e-08
## geneID
## GO:0019902 MAPK8/PTK2/PIK3R1/EGFR/MET/PXN/MAPK1/YWHAE/BCL2/SMAD3/MAPK3/CDH2/MAPT/CDKN1B/CTNNB1/TSC2
## GO:0140297 VHL/ETS1/STAT5A/NCOA3/YAP1/EIF4E/TP53BP1/RB1/PARP1/BCL2/MYC/ARID1A/YWHAZ/GATA3/E2F1/CDKN2A/SMAD3/MAPK3/ESR1/AR/SMAD4/CTNNB1
## GO:0019207 AKT1/CDKN1A/CCND1/PIK3R1/EGFR/CASP3/CCNE1/RICTOR/CCNE2/PIK3CA/CCNB1/CDKN2A/YWHAB/NRG1/AKT1S1/CDKN1B
## GO:0019887 AKT1/CDKN1A/CCND1/EGFR/CASP3/CCNE1/RICTOR/CCNE2/PIK3CA/CCNB1/CDKN2A/YWHAB/NRG1/AKT1S1/CDKN1B
## GO:0019903 MAPK8/PTK2/PIK3R1/EGFR/MET/PXN/YWHAE/BCL2/CDH2/MAPT/CDKN1B/CTNNB1
## GO:0004674 AKT1/MTOR/MAPK8/ATM/CHEK1/EGFR/AKT2/PRKAA1/PRKCA/MAPK1/BRAF/PIK3CA/CDK1/MAPK9/RAF1/MAPK3/GSK3A/ACVRL1
## Count
## GO:0019902 16
## GO:0140297 22
## GO:0019207 16
## GO:0019887 15
## GO:0019903 12
## GO:0004674 18
## ID Description GeneRatio
## GO:0051402 GO:0051402 neuron apoptotic process 26/123
## GO:0048732 GO:0048732 gland development 29/123
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 26/123
## GO:0104004 GO:0104004 cellular response to environmental stimulus 26/123
## GO:0009314 GO:0009314 response to radiation 27/123
## GO:0062197 GO:0062197 cellular response to chemical stress 23/123
## BgRatio pvalue p.adjust qvalue
## GO:0051402 292/18888 2.224843e-22 9.546801e-19 4.295118e-19
## GO:0048732 449/18888 5.318679e-21 7.376703e-18 3.318788e-18
## GO:0071214 334/18888 6.876442e-21 7.376703e-18 3.318788e-18
## GO:0104004 334/18888 6.876442e-21 7.376703e-18 3.318788e-18
## GO:0009314 431/18888 3.167698e-19 2.718518e-16 1.223065e-16
## GO:0062197 311/18888 4.852779e-18 3.470546e-15 1.561403e-15
## geneID
## GO:0051402 FOXO3/ATM/CASP8/KRAS/CCND1/XIAP/AKT2/AXL/MSH2/CASP3/GAPDH/BRAF/RB1/G6PD/PARP1/BCL2/BCL2L11/PIK3CA/BID/BCL2L1/GATA3/CASP9/AKT1S1/GSK3A/COL6A1/CTNNB1
## GO:0048732 AKT1/ATM/CCND1/SRSF1/STAT5A/EGFR/EZH2/MET/AKT2/ITGA2/MAPK1/BRAF/FASN/XBP1/BCL2/BCL2L11/PIK3CA/GATA3/BRCA2/RAF1/SMAD3/MAPK3/ESR1/NRG1/TYMS/AR/CDKN1B/SMAD4/CTNNB1
## GO:0071214 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/PIK3R1/CHEK1/IGF1R/EGFR/PTGS2/AKT2/CASP3/YAP1/ITGA2/TP53BP1/PARP1/MYC/PIK3CA/BCL2L1/GATA3/BRCA2/CASP9/MAPK3/RAD51/ERCC1
## GO:0104004 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/PIK3R1/CHEK1/IGF1R/EGFR/PTGS2/AKT2/CASP3/YAP1/ITGA2/TP53BP1/PARP1/MYC/PIK3CA/BCL2L1/GATA3/BRCA2/CASP9/MAPK3/RAD51/ERCC1
## GO:0009314 AKT1/MAPK8/CDKN1A/ATM/KRAS/CCND1/PIK3R1/KIT/EGFR/AKT2/PRKAA1/MSH2/CASP3/YAP1/TP53BP1/BRAF/MSH6/PARP1/BCL2/MYC/BCL2L1/GATA3/BRCA2/CASP9/COL6A1/RAD51/ERCC1
## GO:0062197 HSPA1A/AKT1/MTOR/MAPK8/FOXO3/ATM/EGFR/EZH2/PTGS2/MET/PRKAA1/PXN/AXL/CASP3/MAPK1/G6PD/PRDX1/PARP1/PIK3CA/CDK1/MAPK9/MAPK3/MAPT
## Count
## GO:0051402 26
## GO:0048732 29
## GO:0071214 26
## GO:0104004 26
## GO:0009314 27
## GO:0062197 23
## ID Description
## GO:0005925 GO:0005925 focal adhesion
## GO:0030055 GO:0030055 cell-substrate junction
## GO:0000781 GO:0000781 chromosome, telomeric region
## GO:0000307 GO:0000307 cyclin-dependent protein kinase holoenzyme complex
## GO:1902911 GO:1902911 protein kinase complex
## GO:0031252 GO:0031252 cell leading edge
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0005925 16/123 421/19894 7.292812e-09 1.231678e-06 6.992379e-07
## GO:0030055 16/123 431/19894 1.015438e-08 1.231678e-06 6.992379e-07
## GO:0000781 11/123 173/19894 1.037931e-08 1.231678e-06 6.992379e-07
## GO:0000307 7/123 56/19894 5.245579e-08 4.668565e-06 2.650398e-06
## GO:1902911 9/123 150/19894 3.922105e-07 2.792539e-05 1.585356e-05
## GO:0031252 13/123 426/19894 2.411709e-06 1.404340e-04 7.972597e-05
## geneID
## GO:0005925 HSPA1A/MYH9/KRAS/PTK2/EGFR/PXN/ITGA2/MAPK1/YWHAE/CTNNA1/YWHAZ/MAPK3/YWHAB/CDH2/ANXA1/CTNNB1
## GO:0030055 HSPA1A/MYH9/KRAS/PTK2/EGFR/PXN/ITGA2/MAPK1/YWHAE/CTNNA1/YWHAZ/MAPK3/YWHAB/CDH2/ANXA1/CTNNB1
## GO:0000781 ATM/CHEK1/EZH2/MSH2/TP53BP1/PARP1/CDK1/BRCA2/XRCC1/RAD51/ERCC1
## GO:0000307 CDKN1A/CCND1/CCNE1/RB1/CCNE2/CDK1/CCNB1
## GO:1902911 CDKN1A/CCND1/IGF1R/PRKAA1/CCNE1/RB1/CCNE2/CDK1/CCNB1
## GO:0031252 AKT1/MYH9/CASP8/EGFR/AKT2/PXN/CTNNA1/TSC1/PIK3CA/NF2/CDH2/MAPT/CTNNB1
## Count
## GO:0005925 16
## GO:0030055 16
## GO:0000781 11
## GO:0000307 7
## GO:1902911 9
## GO:0031252 13
## ID Description GeneRatio
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 19/130
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 22/130
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 18/130
## GO:0045296 GO:0045296 cadherin binding 18/130
## GO:0019902 GO:0019902 phosphatase binding 14/130
## GO:0019903 GO:0019903 protein phosphatase binding 12/130
## BgRatio pvalue p.adjust qvalue
## GO:0044389 324/18522 1.266754e-12 6.738711e-10 3.386596e-10
## GO:0140297 478/18522 2.339830e-12 6.738711e-10 3.386596e-10
## GO:0031625 305/18522 4.666835e-12 8.960324e-10 4.503087e-10
## GO:0045296 333/18522 2.013700e-11 2.899727e-09 1.457283e-09
## GO:0019902 189/18522 6.361969e-11 7.328988e-09 3.683245e-09
## GO:0019903 142/18522 3.430858e-10 3.293623e-08 1.655238e-08
## geneID
## GO:0044389 RB1/HSPA1A/BID/CDKN1A/CASP8/TUBA1B/ERBB3/EGFR/YWHAE/SQSTM1/CCNB1/CHEK2/YWHAZ/CTNNB1/XRCC5/PARP1/SMAD3/NFE2L2/JUN
## GO:0140297 RB1/VHL/ETS1/ARID1A/STAT5A/NCOA3/MYC/YAP1/EIF4E/TP53BP1/STAT3/GATA3/AR/E2F1/YWHAZ/CTNNB1/PARP1/SMAD3/NFE2L2/JUN/PARK7/SRC
## GO:0031625 RB1/HSPA1A/BID/CDKN1A/CASP8/TUBA1B/ERBB3/EGFR/YWHAE/SQSTM1/CHEK2/YWHAZ/CTNNB1/XRCC5/PARP1/SMAD3/NFE2L2/JUN
## GO:0045296 HSPA1A/MYH9/EGFR/YWHAE/ANLN/EEF2/FASN/CTNNA1/ANXA1/YWHAB/CDH2/NDRG1/KDR/PRDX1/YWHAZ/CTNNB1/PARK7/SRC
## GO:0019902 MAPK8/PTK2/PIK3R1/EGFR/MET/PXN/MAPK1/YWHAE/CDH2/STAT3/MAPT/CTNNB1/SMAD3/PIK3R2
## GO:0019903 MAPK8/PTK2/PIK3R1/EGFR/MET/PXN/YWHAE/CDH2/STAT3/MAPT/CTNNB1/PIK3R2
## Count
## GO:0044389 19
## GO:0140297 22
## GO:0031625 18
## GO:0045296 18
## GO:0019902 14
## GO:0019903 12
## ID Description GeneRatio
## GO:0062197 GO:0062197 cellular response to chemical stress 26/130
## GO:0051402 GO:0051402 neuron apoptotic process 25/130
## GO:0006979 GO:0006979 response to oxidative stress 27/130
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 25/130
## GO:0104004 GO:0104004 cellular response to environmental stimulus 25/130
## GO:0000302 GO:0000302 response to reactive oxygen species 21/130
## BgRatio pvalue p.adjust qvalue
## GO:0062197 311/18888 5.021862e-21 2.258331e-17 1.003315e-17
## GO:0051402 292/18888 1.728946e-20 3.887535e-17 1.727126e-17
## GO:0006979 398/18888 1.889315e-19 2.832084e-16 1.258218e-16
## GO:0071214 334/18888 4.539431e-19 3.767813e-16 1.673937e-16
## GO:0104004 334/18888 4.539431e-19 3.767813e-16 1.673937e-16
## GO:0000302 203/18888 5.027102e-19 3.767813e-16 1.673937e-16
## geneID
## GO:0062197 HSPA1A/AKT1/MTOR/MAPK8/FOXO3/ATM/EGFR/EZH2/PTGS2/MET/PRKAA1/PXN/AXL/CASP3/MAPK1/G6PD/CDK1/MAPK9/PRDX1/MAPT/XRCC5/PARP1/NFE2L2/JUN/PARK7/SRC
## GO:0051402 RB1/XIAP/BID/FOXO3/ATM/CASP8/KRAS/CCND1/ERBB3/AKT2/AXL/MSH2/CASP3/GAPDH/BRAF/G6PD/COL6A1/AKT1S1/BCL2L1/KDR/GATA3/CTNNB1/PARP1/PARK7/GSK3A
## GO:0006979 HSPA1A/AKT1/MAPK8/FOXO3/ATM/EGFR/EZH2/PTGS2/MET/PRKAA1/PXN/AXL/CASP3/MAPK1/G6PD/COL6A1/CDK1/MAPK9/PRDX1/MAPT/PARP1/NFE2L2/ERCC1/JUN/PARK7/SRC/XRCC1
## GO:0071214 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/PIK3R1/CHEK1/IGF1R/EGFR/PTGS2/AKT2/MYC/CASP3/YAP1/ITGA2/TP53BP1/BCL2L1/GATA3/BRCA2/CHEK2/XRCC5/PARP1/ERCC1/SNAI2
## GO:0104004 MTOR/MAPK8/CDKN1A/ATM/CASP8/PTEN/PIK3R1/CHEK1/IGF1R/EGFR/PTGS2/AKT2/MYC/CASP3/YAP1/ITGA2/TP53BP1/BCL2L1/GATA3/BRCA2/CHEK2/XRCC5/PARP1/ERCC1/SNAI2
## GO:0000302 AKT1/MAPK8/FOXO3/ATM/EGFR/EZH2/MET/PRKAA1/PXN/AXL/CASP3/MAPK1/COL6A1/CDK1/MAPK9/PRDX1/MAPT/NFE2L2/JUN/PARK7/SRC
## Count
## GO:0062197 26
## GO:0051402 25
## GO:0006979 27
## GO:0071214 25
## GO:0104004 25
## GO:0000302 21
## ID Description GeneRatio BgRatio
## GO:0005925 GO:0005925 focal adhesion 19/130 421/19894
## GO:0030055 GO:0030055 cell-substrate junction 19/130 431/19894
## GO:0000781 GO:0000781 chromosome, telomeric region 12/130 173/19894
## GO:0045121 GO:0045121 membrane raft 12/130 286/19894
## GO:0098857 GO:0098857 membrane microdomain 12/130 287/19894
## GO:1902911 GO:1902911 protein kinase complex 9/130 150/19894
## pvalue p.adjust qvalue
## GO:0005925 3.586150e-11 1.010292e-08 6.121270e-09
## GO:0030055 5.359637e-11 1.010292e-08 6.121270e-09
## GO:0000781 1.510211e-09 1.897832e-07 1.149880e-07
## GO:0045121 3.949491e-07 3.090790e-05 1.872683e-05
## GO:0098857 4.099190e-07 3.090790e-05 1.872683e-05
## GO:1902911 6.275122e-07 3.942869e-05 2.388950e-05
## geneID
## GO:0005925 HSPA1A/MYH9/KRAS/PTK2/EGFR/PXN/ITGA2/MAPK1/YWHAE/TGM2/CTNNA1/ANXA1/YWHAB/CDH2/YWHAZ/CTNNB1/SHC1/PIK3R2/SRC
## GO:0030055 HSPA1A/MYH9/KRAS/PTK2/EGFR/PXN/ITGA2/MAPK1/YWHAE/TGM2/CTNNA1/ANXA1/YWHAB/CDH2/YWHAZ/CTNNB1/SHC1/PIK3R2/SRC
## GO:0000781 ATM/CHEK1/EZH2/MSH2/TP53BP1/CDK1/BRCA2/CHEK2/XRCC5/PARP1/ERCC1/XRCC1
## GO:0045121 IGF1R/EGFR/PTGS2/MAPK1/GAB2/CTNNA1/CDH2/KDR/MAPT/CTNNB1/PARK7/SRC
## GO:0098857 IGF1R/EGFR/PTGS2/MAPK1/GAB2/CTNNA1/CDH2/KDR/MAPT/CTNNB1/PARK7/SRC
## GO:1902911 RB1/CDKN1A/CCND1/IGF1R/PRKAA1/CCNE1/CDK1/CCNB1/XRCC5
## Count
## GO:0005925 19
## GO:0030055 19
## GO:0000781 12
## GO:0045121 12
## GO:0098857 12
## GO:1902911 9
## ID Description GeneRatio
## GO:0097718 GO:0097718 disordered domain specific binding 4/32
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 7/32
## GO:0120283 GO:0120283 protein serine/threonine kinase binding 2/32
## GO:0003713 GO:0003713 transcription coactivator activity 5/32
## GO:0005178 GO:0005178 integrin binding 4/32
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 5/32
## BgRatio pvalue p.adjust qvalue
## GO:0097718 32/18522 2.549897e-07 5.788265e-05 2.657261e-05
## GO:0140297 478/18522 1.403336e-05 1.592786e-03 7.312120e-04
## GO:0120283 7/18522 6.039943e-05 4.570223e-03 2.098085e-03
## GO:0003713 271/18522 9.416390e-05 5.343801e-03 2.453217e-03
## GO:0005178 157/18522 1.484910e-04 6.197478e-03 2.845121e-03
## GO:0031625 305/18522 1.638100e-04 6.197478e-03 2.845121e-03
## geneID Count
## GO:0097718 HSPA1A/NCOA3/GAPDH/CTNNB1 4
## GO:0140297 VHL/STAT5A/YAP1/ETS1/ARID1A/NCOA3/CTNNB1 7
## GO:0120283 MAPK8/XIAP 2
## GO:0003713 YAP1/ETS1/ARID1A/NCOA3/CTNNB1 5
## GO:0005178 MYH9/PTK2/ITGA2/FN1 4
## GO:0031625 HSPA1A/CDKN1A/CASP8/BID/CTNNB1 5
## ID Description GeneRatio BgRatio
## GO:0051402 GO:0051402 neuron apoptotic process 10/32 292/18888
## GO:0030099 GO:0030099 myeloid cell differentiation 10/32 439/18888
## GO:0001667 GO:0001667 ameboidal-type cell migration 10/32 498/18888
## GO:0010631 GO:0010631 epithelial cell migration 9/32 375/18888
## GO:0090132 GO:0090132 epithelium migration 9/32 378/18888
## GO:0090130 GO:0090130 tissue migration 9/32 383/18888
## pvalue p.adjust qvalue
## GO:0051402 3.194726e-11 7.731238e-08 3.298975e-08
## GO:0030099 1.696073e-09 2.052248e-06 8.757092e-07
## GO:0001667 5.685674e-09 3.953413e-06 1.686950e-06
## GO:0010631 8.161692e-09 3.953413e-06 1.686950e-06
## GO:0090132 8.746054e-09 3.953413e-06 1.686950e-06
## GO:0090130 9.801852e-09 3.953413e-06 1.686950e-06
## geneID Count
## GO:0051402 FOXO3/ATM/CASP8/CCND1/XIAP/BID/KRAS/G6PD/GAPDH/CTNNB1 10
## GO:0030099 HSPA1A/MTOR/STAT5A/MYH9/FOXO3/CASP8/ETS1/GAB2/G6PD/CTNNB1 10
## GO:0001667 AKT1/MTOR/STAT5A/MYH9/ANLN/ETS1/PTEN/PTK2/ITGA2/FN1 10
## GO:0010631 AKT1/MTOR/STAT5A/MYH9/ANLN/ETS1/PTEN/PTK2/ITGA2 9
## GO:0090132 AKT1/MTOR/STAT5A/MYH9/ANLN/ETS1/PTEN/PTK2/ITGA2 9
## GO:0090130 AKT1/MTOR/STAT5A/MYH9/ANLN/ETS1/PTEN/PTK2/ITGA2 9
## ID Description GeneRatio BgRatio
## GO:0005925 GO:0005925 focal adhesion 8/32 421/19894
## GO:0030055 GO:0030055 cell-substrate junction 8/32 431/19894
## GO:0005826 GO:0005826 actomyosin contractile ring 2/32 4/19894
## GO:0005741 GO:0005741 mitochondrial outer membrane 5/32 219/19894
## GO:0031968 GO:0031968 organelle outer membrane 5/32 248/19894
## GO:0019867 GO:0019867 outer membrane 5/32 250/19894
## pvalue p.adjust qvalue
## GO:0005925 2.536321e-07 2.728748e-05 1.436183e-05
## GO:0030055 3.031942e-07 2.728748e-05 1.436183e-05
## GO:0005826 1.500952e-05 9.005712e-04 4.739849e-04
## GO:0005741 2.440940e-05 1.098423e-03 5.781174e-04
## GO:0031968 4.422395e-05 1.378405e-03 7.254762e-04
## GO:0019867 4.594683e-05 1.378405e-03 7.254762e-04
## geneID Count
## GO:0005925 HSPA1A/MYH9/MAPK1/KRAS/PTK2/ITGA2/CTNNB1/TGM2 8
## GO:0030055 HSPA1A/MYH9/MAPK1/KRAS/PTK2/ITGA2/CTNNB1/TGM2 8
## GO:0005826 MYH9/ANLN 2
## GO:0005741 MTOR/FOXO3/CASP8/BID/KRAS 5
## GO:0031968 MTOR/FOXO3/CASP8/BID/KRAS 5
## GO:0019867 MTOR/FOXO3/CASP8/BID/KRAS 5
## ID Description GeneRatio
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 9/58
## GO:0030235 GO:0030235 nitric-oxide synthase regulator activity 3/58
## GO:0019902 GO:0019902 phosphatase binding 7/58
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 10/58
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 8/58
## GO:0001618 GO:0001618 virus receptor activity 5/58
## BgRatio pvalue p.adjust qvalue
## GO:0044389 324/18522 6.881594e-07 0.0001723522 7.076044e-05
## GO:0030235 7/18522 1.010863e-06 0.0001723522 7.076044e-05
## GO:0019902 189/18522 1.996676e-06 0.0001748303 7.177785e-05
## GO:0140297 478/18522 2.050796e-06 0.0001748303 7.177785e-05
## GO:0031625 305/18522 4.625247e-06 0.0002269983 9.319580e-05
## GO:0001618 79/18522 4.767238e-06 0.0002269983 9.319580e-05
## geneID Count
## GO:0044389 HSPA1A/CDKN1A/CASP8/BCL2/BID/YWHAZ/TUBA1B/EGFR/CCNB1 9
## GO:0030235 AKT1/ESR1/EGFR 3
## GO:0019902 MAPK8/MAPK1/MET/BCL2/PTK2/PIK3R1/EGFR 7
## GO:0140297 VHL/STAT5A/YAP1/ESR1/BCL2/ETS1/ARID1A/YWHAZ/NCOA3/GATA3 10
## GO:0031625 HSPA1A/CDKN1A/CASP8/BCL2/BID/YWHAZ/TUBA1B/EGFR 8
## GO:0001618 HSPA1A/ITGA2/CDK1/TFRC/EGFR 5
## ID Description GeneRatio
## GO:0031667 GO:0031667 response to nutrient levels 16/58
## GO:0071496 GO:0071496 cellular response to external stimulus 14/58
## GO:0048732 GO:0048732 gland development 15/58
## GO:0045785 GO:0045785 positive regulation of cell adhesion 15/58
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 13/58
## GO:0104004 GO:0104004 cellular response to environmental stimulus 13/58
## BgRatio pvalue p.adjust qvalue
## GO:0031667 490/18888 9.688790e-13 1.736571e-09 8.040361e-10
## GO:0071496 335/18888 1.167050e-12 1.736571e-09 8.040361e-10
## GO:0048732 449/18888 4.050549e-12 4.018145e-09 1.860410e-09
## GO:0045785 485/18888 1.212227e-11 9.018970e-09 4.175804e-09
## GO:0071214 334/18888 2.021181e-11 1.002506e-08 4.641624e-09
## GO:0104004 334/18888 2.021181e-11 1.002506e-08 4.641624e-09
## geneID
## GO:0031667 AKT1/MTOR/MAPK8/CDKN1A/FOXO3/MAPK1/G6PD/BCL2/IGF1R/YWHAZ/ITGA2/IGFBP2/TSC1/XBP1/TFRC/EGFR
## GO:0071496 MTOR/MAPK8/CDKN1A/FOXO3/CASP8/MAPK1/BCL2/IGF1R/YWHAZ/CHEK1/ITGA2/TSC1/XBP1/EGFR
## GO:0048732 AKT1/ATM/STAT5A/CCND1/MAPK1/ESR1/MET/BCL2/ITGA2/TGM2/SRSF1/FASN/GATA3/XBP1/EGFR
## GO:0045785 AKT1/MTOR/FOXO3/ATM/ETS1/ARID1A/FN1/ITGA2/TGM2/IGFBP2/GATA3/TSC1/XBP1/TFRC/PREX1
## GO:0071214 MTOR/MAPK8/CDKN1A/ATM/CASP8/YAP1/IGF1R/PTEN/CHEK1/ITGA2/PIK3R1/GATA3/EGFR
## GO:0104004 MTOR/MAPK8/CDKN1A/ATM/CASP8/YAP1/IGF1R/PTEN/CHEK1/ITGA2/PIK3R1/GATA3/EGFR
## Count
## GO:0031667 16
## GO:0071496 14
## GO:0048732 15
## GO:0045785 15
## GO:0071214 13
## GO:0104004 13
## ID Description
## GO:0005925 GO:0005925 focal adhesion
## GO:0030055 GO:0030055 cell-substrate junction
## GO:0097125 GO:0097125 cyclin B1-CDK1 complex
## GO:0000307 GO:0000307 cyclin-dependent protein kinase holoenzyme complex
## GO:0005741 GO:0005741 mitochondrial outer membrane
## GO:0005826 GO:0005826 actomyosin contractile ring
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0005925 9/58 421/19894 3.324184e-06 0.000418428 0.0002477534
## GO:0030055 9/58 431/19894 4.023346e-06 0.000418428 0.0002477534
## GO:0097125 2/58 2/19894 8.353730e-06 0.000579192 0.0003429426
## GO:0000307 4/58 56/19894 2.133362e-05 0.001109348 0.0006568509
## GO:0005741 6/58 219/19894 4.172625e-05 0.001731061 0.0010249700
## GO:0005826 2/58 4/19894 4.993444e-05 0.001731061 0.0010249700
## geneID Count
## GO:0005925 HSPA1A/MYH9/MAPK1/KRAS/PTK2/YWHAZ/ITGA2/TGM2/EGFR 9
## GO:0030055 HSPA1A/MYH9/MAPK1/KRAS/PTK2/YWHAZ/ITGA2/TGM2/EGFR 9
## GO:0097125 CDK1/CCNB1 2
## GO:0000307 CDKN1A/CCND1/CDK1/CCNB1 4
## GO:0005741 MTOR/FOXO3/CASP8/BCL2/KRAS/BID 6
## GO:0005826 MYH9/ANLN 2
## ID Description GeneRatio
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 26/154
## GO:0019902 GO:0019902 phosphatase binding 18/154
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 22/154
## GO:0031625 GO:0031625 ubiquitin protein ligase binding 21/154
## GO:0019903 GO:0019903 protein phosphatase binding 15/154
## GO:0004674 GO:0004674 protein serine/threonine kinase activity 22/154
## BgRatio pvalue p.adjust qvalue
## GO:0140297 478/18522 2.427346e-14 6.417153e-12 3.244205e-12
## GO:0019902 189/18522 2.503227e-14 6.417153e-12 3.244205e-12
## GO:0044389 324/18522 3.302137e-14 6.417153e-12 3.244205e-12
## GO:0031625 305/18522 1.007656e-13 1.468659e-11 7.424835e-12
## GO:0019903 142/18522 8.689144e-13 1.013154e-10 5.122022e-11
## GO:0004674 427/18522 8.385438e-12 8.147851e-10 4.119163e-10
## geneID
## GO:0140297 GATA3/AR/CTNNB1/YWHAZ/PARP1/ESR1/BCL2/NCOA3/RB1/MYC/JUN/ETS1/STAT5A/STAT3/GSK3B/ARID1A/E2F1/YAP1/EIF4E/TP53BP1/SMAD4/VHL/PARK7/CDKN2A/SMAD3/MAPK3
## GO:0019902 CTNNB1/CDH2/PIK3R1/PXN/PIK3R2/YWHAE/MET/BCL2/PTK2/CDKN1B/EGFR/STAT3/MAPT/MAPK8/MAPK1/RPS6KB1/SMAD3/MAPK3
## GO:0044389 SQSTM1/HSPA1A/CTNNB1/TUBA1B/CDKN1A/ERBB3/YWHAZ/YWHAE/PARP1/CCNB1/BCL2/RB1/CDKN1B/EGFR/JUN/CASP8/GSK3B/BID/CHEK2/BECN1/SMAD1/SMAD3
## GO:0031625 SQSTM1/HSPA1A/CTNNB1/TUBA1B/CDKN1A/ERBB3/YWHAZ/YWHAE/PARP1/BCL2/RB1/CDKN1B/EGFR/JUN/CASP8/GSK3B/BID/CHEK2/BECN1/SMAD1/SMAD3
## GO:0019903 CTNNB1/CDH2/PIK3R1/PXN/PIK3R2/YWHAE/MET/BCL2/PTK2/CDKN1B/EGFR/STAT3/MAPT/MAPK8/RPS6KB1
## GO:0004674 ATM/PRKCA/CDK1/AKT2/EGFR/RAF1/AKT1/CHEK1/GSK3B/PRKAA1/MAPK8/CHEK2/PRKCD/PIK3CA/MAPK1/RPS6KB1/NEK7/BRAF/EEF2K/ACVRL1/MAPK9/MAPK3
## Count
## GO:0140297 26
## GO:0019902 18
## GO:0044389 22
## GO:0031625 21
## GO:0019903 15
## GO:0004674 22
## ID Description GeneRatio BgRatio
## GO:0051402 GO:0051402 neuron apoptotic process 30/154 292/18888
## GO:0043434 GO:0043434 response to peptide hormone 33/154 438/18888
## GO:0010038 GO:0010038 response to metal ion 29/154 360/18888
## GO:0062197 GO:0062197 cellular response to chemical stress 27/154 311/18888
## GO:0000302 GO:0000302 response to reactive oxygen species 23/154 203/18888
## GO:0097191 GO:0097191 extrinsic apoptotic signaling pathway 24/154 230/18888
## pvalue p.adjust qvalue
## GO:0051402 1.491941e-24 7.234423e-21 3.236727e-21
## GO:0043434 1.157285e-22 2.805838e-19 1.255350e-19
## GO:0010038 9.275171e-21 1.499177e-17 6.707413e-18
## GO:0062197 3.285101e-20 3.982363e-17 1.781735e-17
## GO:0000302 6.154374e-20 5.214606e-17 2.333048e-17
## GO:0097191 6.452389e-20 5.214606e-17 2.333048e-17
## geneID
## GO:0051402 GAPDH/GATA3/ATM/G6PD/MSH2/CTNNB1/CCND1/COL6A1/ERBB3/PARP1/KDR/BCL2L1/AKT2/BCL2/KRAS/RB1/BCL2L11/FOXO3/XIAP/CASP8/GSK3B/BID/AXL/CASP3/PIK3CA/DIABLO/BRAF/AKT1S1/PARK7/CASP9
## GO:0043434 PRKCA/PIK3R1/COL6A1/PXN/ERRFI1/PIK3R2/PARP1/AKT2/RB1/PTK2/CDKN1B/IRS1/RAF1/PTGS2/SHC1/AKT1/STAT5A/STAT3/GSK3B/IGF1R/PRKAA1/PRKCD/CAV1/TFF1/PIK3CA/MAPK1/RPS6KB1/BRAF/EEF2K/TSC1/XBP1/SMAD3/MAPK3
## GO:0010038 TFRC/G6PD/NDRG1/PARP1/CDK1/BCL2/KIT/CDKN1B/EGFR/JUN/PTGS2/AKT1/CASP8/MAPT/PRKAA1/MAPK8/CAV1/CASP3/TFF1/MAPK1/NEK7/ERCC1/BRAF/BECN1/EEF2K/PARK7/CASP9/MAPK9/MAPK3
## GO:0062197 ATM/G6PD/HSPA1A/PXN/PARP1/CDK1/MET/EGFR/JUN/EZH2/PTGS2/FOXO3/AKT1/MAPT/PRKAA1/MAPK8/PRKCD/AXL/CAV1/CASP3/PRDX1/PIK3CA/MAPK1/BECN1/PARK7/MAPK9/MAPK3
## GO:0000302 ATM/COL6A1/PXN/CDK1/MET/BCL2/EGFR/JUN/EZH2/FOXO3/AKT1/MAPT/PRKAA1/MAPK8/PRKCD/AXL/CASP3/PRDX1/MAPK1/BECN1/PARK7/MAPK9/MAPK3
## GO:0097191 AR/HSPA1A/SERPINE1/PIK3R1/PEA15/CTNNA1/ERBB3/BCL2L1/BCL2/BCL2L11/RAF1/FOXO3/AKT1/CASP8/GSK3B/BID/CAV1/YAP1/RET/RPS6KB1/DIABLO/SMAD4/PARK7/SMAD3
## Count
## GO:0051402 30
## GO:0043434 33
## GO:0010038 29
## GO:0062197 27
## GO:0000302 23
## GO:0097191 24
## ID
## GO:0005925 GO:0005925
## GO:0030055 GO:0030055
## GO:0000781 GO:0000781
## GO:0045121 GO:0045121
## GO:0098857 GO:0098857
## GO:0061695 GO:0061695
## Description
## GO:0005925 focal adhesion
## GO:0030055 cell-substrate junction
## GO:0000781 chromosome, telomeric region
## GO:0045121 membrane raft
## GO:0098857 membrane microdomain
## GO:0061695 transferase complex, transferring phosphorus-containing groups
## GeneRatio BgRatio pvalue p.adjust qvalue
## GO:0005925 20/154 421/19894 9.803904e-11 2.954678e-08 1.703570e-08
## GO:0030055 20/154 431/19894 1.484763e-10 2.954678e-08 1.703570e-08
## GO:0000781 12/154 173/19894 1.047443e-08 1.389607e-06 8.012017e-07
## GO:0045121 14/154 286/19894 5.109761e-08 4.247742e-06 2.449108e-06
## GO:0098857 14/154 287/19894 5.336360e-08 4.247742e-06 2.449108e-06
## GO:0061695 14/154 308/19894 1.276192e-07 8.465410e-06 4.880876e-06
## geneID
## GO:0005925 HSPA1A/CTNNB1/TGM2/CDH2/CTNNA1/ANXA1/YWHAZ/YWHAB/PXN/PIK3R2/ITGA2/MYH9/YWHAE/KRAS/PTK2/EGFR/SHC1/CAV1/MAPK1/MAPK3
## GO:0030055 HSPA1A/CTNNB1/TGM2/CDH2/CTNNA1/ANXA1/YWHAZ/YWHAB/PXN/PIK3R2/ITGA2/MYH9/YWHAE/KRAS/PTK2/EGFR/SHC1/CAV1/MAPK1/MAPK3
## GO:0000781 ATM/MSH2/PARP1/CDK1/EZH2/CHEK1/CHEK2/ERCC1/TP53BP1/RAD50/RAD51/XRCC1
## GO:0045121 CTNNB1/CDH2/CTNNA1/KDR/IRS1/EGFR/PTGS2/IGF1R/MAPT/CAV1/MAPK1/GAB2/PARK7/MAPK3
## GO:0098857 CTNNB1/CDH2/CTNNA1/KDR/IRS1/EGFR/PTGS2/IGF1R/MAPT/CAV1/MAPK1/GAB2/PARK7/MAPK3
## GO:0061695 CCND1/PIK3R1/CDKN1A/PIK3R2/CDK1/CCNB1/RB1/IRS1/IGF1R/PRKAA1/CCNE2/CCNE1/PIK3CA/BECN1
## Count
## GO:0005925 20
## GO:0030055 20
## GO:0000781 12
## GO:0045121 14
## GO:0098857 14
## GO:0061695 14
## ID Description GeneRatio
## GO:0019902 GO:0019902 phosphatase binding 24/197
## GO:0004674 GO:0004674 protein serine/threonine kinase activity 31/197
## GO:0140297 GO:0140297 DNA-binding transcription factor binding 32/197
## GO:0019903 GO:0019903 protein phosphatase binding 19/197
## GO:0106310 GO:0106310 protein serine kinase activity 27/197
## GO:0044389 GO:0044389 ubiquitin-like protein ligase binding 25/197
## BgRatio pvalue p.adjust qvalue
## GO:0019902 189/18522 3.522311e-19 2.345859e-16 1.338478e-16
## GO:0004674 427/18522 2.437307e-17 8.116233e-15 4.630884e-15
## GO:0140297 478/18522 7.451383e-17 1.654207e-14 9.438419e-15
## GO:0019903 142/18522 7.820802e-16 1.302164e-13 7.429762e-14
## GO:0106310 363/18522 1.829155e-15 2.436434e-13 1.390158e-13
## GO:0044389 324/18522 9.403920e-15 1.043835e-12 5.955816e-13
## geneID
## GO:0019902 MAPK14/CDKN1B/MAPK8/CDH2/MET/TP53/SMAD3/MAPK1/EGFR/YWHAE/MAPK3/TSC2/CTNNB1/MAPT/STAT3/PTK2/BCL2/LCK/PIK3R1/RPS6KB1/PIK3R2/PXN/SYK/BAD
## GO:0004674 MAPK14/MAPK8/PRKCD/RPS6KA1/AKT2/AKT3/AKT1/PIK3CA/RAF1/ATM/MAPK1/NEK7/MAPK9/STK11/EGFR/MTOR/MAPK3/ACVRL1/CHEK2/PRKCA/CHEK1/GSK3B/GSK3A/CDK1/EEF2K/BRAF/ARAF/RPS6KB1/MAP2K1/PRKAA1/SYK
## GO:0140297 MAPK14/YAP1/SRC/TP53/RB1/ESR1/GATA3/SMAD3/TP53BP1/YWHAZ/MAPK3/PCNA/SMAD4/CTNNB1/NFE2L2/JUN/EIF4E/STAT3/GSK3B/PARK7/BCL2/ETS1/KEAP1/E2F1/MYC/VHL/AR/NCOA3/STAT5A/ARID1A/PARP1/CDKN2A
## GO:0019903 MAPK14/CDKN1B/MAPK8/CDH2/MET/TP53/EGFR/YWHAE/CTNNB1/MAPT/STAT3/PTK2/BCL2/LCK/PIK3R1/RPS6KB1/PIK3R2/PXN/BAD
## GO:0106310 MAPK14/MAPK8/PRKCD/RPS6KA1/AKT2/AKT3/AKT1/PIK3CA/RAF1/ATM/MAPK1/NEK7/MAPK9/STK11/MTOR/MAPK3/CHEK2/PRKCA/CHEK1/GSK3B/GSK3A/CDK1/BRAF/ARAF/RPS6KB1/MAP2K1/PRKAA1
## GO:0044389 CDKN1B/ERBB3/TP53/BECN1/RB1/CDKN1A/SMAD3/YWHAZ/XRCC5/EGFR/YWHAE/CHEK2/CTNNB1/NFE2L2/SMAD1/JUN/GSK3B/BCL2/CCNB1/TUBA1B/BID/HSPA1A/PARP1/CASP8/SQSTM1
## Count
## GO:0019902 24
## GO:0004674 31
## GO:0140297 32
## GO:0019903 19
## GO:0106310 27
## GO:0044389 25
## ID Description GeneRatio
## GO:0048732 GO:0048732 gland development 45/198
## GO:0071214 GO:0071214 cellular response to abiotic stimulus 40/198
## GO:0104004 GO:0104004 cellular response to environmental stimulus 40/198
## GO:0050673 GO:0050673 epithelial cell proliferation 44/198
## GO:0097193 GO:0097193 intrinsic apoptotic signaling pathway 37/198
## GO:0043434 GO:0043434 response to peptide hormone 41/198
## BgRatio pvalue p.adjust qvalue
## GO:0048732 449/18888 2.873605e-31 1.501068e-27 6.678896e-28
## GO:0071214 334/18888 8.418777e-31 1.501068e-27 6.678896e-28
## GO:0104004 334/18888 8.418777e-31 1.501068e-27 6.678896e-28
## GO:0050673 482/18888 7.666647e-29 1.025222e-25 4.561655e-26
## GO:0097193 319/18888 5.519756e-28 5.905035e-25 2.627404e-25
## GO:0043434 438/18888 2.745077e-27 2.447236e-24 1.088880e-24
## geneID
## GO:0048732 CDKN1B/RPS6KA1/BCL2L11/SRC/AKT2/AKT1/MET/ESR1/PIK3CA/GATA3/SMAD3/RAF1/ATM/MAPK1/NOTCH1/ITGA2/STK11/BRCA2/EGFR/FASN/MAPK3/PCNA/SMAD4/CTNNB1/CDH1/TGM2/BCL2/NFKB1/CCND1/CAV1/AR/XBP1/TP63/TYMS/BRAF/PTCH1/NRG1/MAP2K1/STAT5A/PGR/EZH2/BAX/ERRFI1/SNAI2/SRSF1
## GO:0071214 MAPK14/YAP1/MAPK8/PRKCD/AKT2/RAD51/TP53/IGF1R/PTEN/PIK3CA/CDKN1A/GATA3/ATM/TP53BP1/XRCC5/ITGA2/STK11/BRCA2/EGFR/MTOR/MAPK3/PCNA/CHEK2/BAK1/CHEK1/RAB11B/NFKB1/MYC/PIK3R1/BCL2L1/ERCC1/BAX/PTGS2/PARP1/CASP9/CASP3/RPTOR/BAD/SNAI2/CASP8
## GO:0104004 MAPK14/YAP1/MAPK8/PRKCD/AKT2/RAD51/TP53/IGF1R/PTEN/PIK3CA/CDKN1A/GATA3/ATM/TP53BP1/XRCC5/ITGA2/STK11/BRCA2/EGFR/MTOR/MAPK3/PCNA/CHEK2/BAK1/CHEK1/RAB11B/NFKB1/MYC/PIK3R1/BCL2L1/ERCC1/BAX/PTGS2/PARP1/CASP9/CASP3/RPTOR/BAD/SNAI2/CASP8
## GO:0050673 YAP1/CDKN1B/ERBB2/KDR/RPS6KA1/AKT3/AKT1/NRAS/RB1/ESR1/CDKN1A/GATA3/SMAD3/RAF1/MAPK1/NOTCH1/STK11/BRCA2/EGFR/ACVRL1/BAK1/CTNNB1/CDH3/PRKCA/RICTOR/STAT3/MYC/CCND1/CAV1/AR/XBP1/BCL2L1/TP63/KIT/PTCH1/MAP2K1/STAT5A/PGR/BAX/BID/ERRFI1/RPTOR/BAD/SNAI2
## GO:0097193 PRKCD/BCL2L11/SRC/AKT1/TP53/BECN1/CDKN1A/ATM/STK11/BRCA2/CHEK2/BAK1/CTNNB1/NFE2L2/PARK7/BCL2/LCK/E2F1/MYC/CAV1/PIK3R1/XBP1/BCL2L1/TP63/MSH6/PDK1/BAX/BID/HSPA1A/PTGS2/PARP1/CASP9/CASP3/BAD/SNAI2/MSH2/DIABLO
## GO:0043434 MAPK14/CDKN1B/PRKCD/SRC/AKT2/AKT1/IGF1R/RB1/PIK3CA/SMAD3/RAF1/MAPK1/STK11/MTOR/MAPK3/TSC1/TSC2/NFE2L2/PRKCA/SHC1/STAT3/GSK3B/GSK3A/PTK2/EEF2K/NFKB1/IRS1/CAV1/PIK3R1/XBP1/BRAF/RPS6KB1/PRKAA1/COL6A1/STAT5A/PIK3R2/PXN/PTGS2/ERRFI1/PARP1/TFF1
## Count
## GO:0048732 45
## GO:0071214 40
## GO:0104004 40
## GO:0050673 44
## GO:0097193 37
## GO:0043434 41
## ID Description GeneRatio BgRatio
## GO:0045121 GO:0045121 membrane raft 20/198 286/19894
## GO:0098857 GO:0098857 membrane microdomain 20/198 287/19894
## GO:0005925 GO:0005925 focal adhesion 23/198 421/19894
## GO:0030055 GO:0030055 cell-substrate junction 23/198 431/19894
## GO:0044853 GO:0044853 plasma membrane raft 13/198 113/19894
## GO:0097136 GO:0097136 Bcl-2 family protein complex 6/198 10/19894
## pvalue p.adjust qvalue
## GO:0045121 9.650977e-12 2.293508e-09 1.391153e-09
## GO:0098857 1.028479e-11 2.293508e-09 1.391153e-09
## GO:0005925 3.861965e-11 5.741454e-09 3.482543e-09
## GO:0030055 6.170201e-11 6.879774e-09 4.173005e-09
## GO:0044853 1.017449e-10 9.075645e-09 5.504935e-09
## GO:0097136 1.830473e-10 1.340131e-08 8.128717e-09
## geneID
## GO:0045121 KDR/SRC/CDH2/IGF1R/MAPK1/EGFR/MAPK3/PECAM1/CTNNB1/MAPT/CDH1/PARK7/MS4A1/LCK/CTNNA1/IRS1/CAV1/PTCH1/GAB2/PTGS2
## GO:0098857 KDR/SRC/CDH2/IGF1R/MAPK1/EGFR/MAPK3/PECAM1/CTNNB1/MAPT/CDH1/PARK7/MS4A1/LCK/CTNNA1/IRS1/CAV1/PTCH1/GAB2/PTGS2
## GO:0005925 SRC/CDH2/MAPK1/YWHAZ/VASP/ITGA2/EGFR/YWHAE/MAPK3/CTNNB1/SHC1/PTK2/TGM2/CTNNA1/CAV1/MYH9/KRAS/MAP2K1/YWHAB/PIK3R2/ANXA1/HSPA1A/PXN
## GO:0030055 SRC/CDH2/MAPK1/YWHAZ/VASP/ITGA2/EGFR/YWHAE/MAPK3/CTNNB1/SHC1/PTK2/TGM2/CTNNA1/CAV1/MYH9/KRAS/MAP2K1/YWHAB/PIK3R2/ANXA1/HSPA1A/PXN
## GO:0044853 SRC/CDH2/IGF1R/MAPK1/MAPK3/CTNNB1/CDH1/MS4A1/CTNNA1/IRS1/CAV1/PTCH1/PTGS2
## GO:0097136 BCL2L11/BAK1/BCL2/BCL2L1/BAX/BAD
## Count
## GO:0045121 20
## GO:0098857 20
## GO:0005925 23
## GO:0030055 23
## GO:0044853 13
## GO:0097136 6barplot(ego_MF[[1]], title = "enrichGO, Molecular Function, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ego_MF[[2]], title = "enrichGO, Molecular Function, \n All Selected Genes, Cox Regression Glmnet")
barplot(ego_MF[[3]], title = "enrichGO, Molecular Function, \n All Selected Genes, Squeezy")
barplot(ego_MF[[4]], title = "enrichGO, Molecular Function, \n All Selected Genes, Globaltest")
barplot(ego_MF[[5]], title = "enrichGO, Molecular Function, \n All Selected Genes, FABIA")
barplot(ego_MF[[6]], title = "enrichGO, Molecular Function, \n All Selected Genes, MOFA")
barplot(ego_MF[[7]], title = "enrichGO, Molecular Function, \n All Selected Genes, MFA")
barplot(ego_MF[[8]], title = "enrichGO, Molecular Function, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ego_MF[[9]], title = "enrichGO, Molecular Function, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ego_MF[[10]], title = "enrichGO, Molecular Function, \n All Selected Genes, Gaussian Graphical Models")
barplot(ego_MF[[11]], title = "enrichGO, Molecular Function, \n All Genes in ACC Dataset")
barplot(ego_BP[[1]], title = "enrichGO, Biological Process, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ego_BP[[2]], title = "enrichGO, Biological Process, \n All Selected Genes, Cox Regression Glmnet")
barplot(ego_BP[[3]], title = "enrichGO, Biological Process, \n All Selected Genes, Squeezy")
barplot(ego_BP[[4]], title = "enrichGO, Biological Process, \n All Selected Genes, Globaltest")
barplot(ego_BP[[5]], title = "enrichGO, Biological Process, \n All Selected Genes, FABIA")
barplot(ego_BP[[6]], title = "enrichGO, Biological Process, \n All Selected Genes, MOFA")
barplot(ego_BP[[7]], title = "enrichGO, Biological Process, \n All Selected Genes, MFA")
barplot(ego_BP[[8]], title = "enrichGO, Biological Process, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ego_BP[[9]], title = "enrichGO, Biological Process, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ego_BP[[10]], title = "enrichGO, Biological Process, \n All Selected Genes, Gaussian Graphical Models")
barplot(ego_BP[[11]], title = "enrichGO, Biological Process, \n All Genes in ACC Dataset")
barplot(ego_CC[[1]], title = "enrichGO, Cellular Component, \n All Selected Genes, Logistic Regression Glmnet")
barplot(ego_CC[[2]], title = "enrichGO, Cellular Component, \n All Selected Genes, Cox Regression Glmnet")
barplot(ego_CC[[3]], title = "enrichGO, Cellular Component, \n All Selected Genes, Squeezy")
barplot(ego_CC[[4]], title = "enrichGO, Cellular Component, \n All Selected Genes, Globaltest")
barplot(ego_CC[[5]], title = "enrichGO, Cellular Component, \n All Selected Genes, FABIA")
barplot(ego_CC[[6]], title = "enrichGO, Cellular Component, \n All Selected Genes, MOFA")
barplot(ego_CC[[7]], title = "enrichGO, Cellular Component, \n All Selected Genes, MFA")
barplot(ego_CC[[8]], title = "enrichGO, Cellular Component, \n All Selected Genes, 20 FABIA Ensemble")
barplot(ego_CC[[9]], title = "enrichGO, Cellular Component, \n All Selected Genes, FABIA & MOFA Ensemble")
barplot(ego_CC[[10]], title = "enrichGO, Cellular Component, \n All Selected Genes, Gaussian Graphical Models")
barplot(ego_CC[[11]], title = "enrichGO, Cellular Component, \n All Genes in ACC Dataset")
DAG plots for ego
goplot(ego_MF[[1]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, Logistic Regression Glmnet")
goplot(ego_MF[[2]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, Cox Regression Glmnet")
goplot(ego_MF[[3]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, Squeezy")
goplot(ego_MF[[4]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, Globaltest")
goplot(ego_MF[[5]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, FABIA")
goplot(ego_MF[[6]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, MOFA")
goplot(ego_MF[[7]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, MFA")
goplot(ego_MF[[8]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, 20 FABIA Ensemble")
goplot(ego_MF[[9]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, FABIA & MOFA Ensemble")
goplot(ego_MF[[10]]) + labs(title = "enrichGO, Molecular Function, \n All Selected Genes, Gaussian Graphical Models")
goplot(ego_MF[[11]]) + labs(title = "enrichGO, Molecular Function, \n All Genes in ACC Dataset")
goplot(ego_BP[[1]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, Logistic Regression Glmnet")
goplot(ego_BP[[2]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, Cox Regression Glmnet")## Warning: ggrepel: 11 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
goplot(ego_BP[[3]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, Squeezy")
goplot(ego_BP[[4]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, Globaltest")
goplot(ego_BP[[5]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, FABIA")
goplot(ego_BP[[6]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, MOFA")
goplot(ego_BP[[7]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, MFA")
goplot(ego_BP[[8]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, 20 FABIA Ensemble")
goplot(ego_BP[[9]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, FABIA & MOFA Ensemble")
goplot(ego_BP[[10]]) + labs(title = "enrichGO, Biological Process, \n All Selected Genes, Gaussian Graphical Models")
goplot(ego_BP[[11]]) + labs(title = "enrichGO, Biological Process, \n All Genes in ACC Dataset")
goplot(ego_CC[[1]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, Logistic Regression Glmnet")
goplot(ego_CC[[2]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, Cox Regression Glmnet")
goplot(ego_CC[[3]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, Squeezy")
goplot(ego_CC[[4]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, Globaltest")
goplot(ego_CC[[5]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, FABIA")
goplot(ego_CC[[6]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, MOFA")
goplot(ego_CC[[7]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, MFA")
goplot(ego_CC[[8]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, 20 FABIA Ensemble")
goplot(ego_CC[[9]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, FABIA & MOFA Ensemble")
goplot(ego_CC[[10]]) + labs(title = "enrichGO, Cellular Component, \n All Selected Genes, Gaussian Graphical Models")
goplot(ego_CC[[11]]) + labs(title = "enrichGO, Cellular Component, \n All Genes in ACC Dataset")
3. Export Pathway Analysis result to data
pathway = list("ggo_MF" = ggo_MF,
"ggo_BP" = ggo_BP,
"ggo_CC" = ggo_CC,
"ego_MF" = ego_MF,
"ego_BP" = ego_BP,
"ego_CC" = ego_CC)
saveRDS(pathway, file = "data/out_pathway/pathways_methods_merged.rds")